Download PGS
(Variants and weights)

Polygenic Score (PGS) ID: PGS000010

Predicted Trait

Reported Trait: Coronary heart disease
Mapped Trait(s) (Experimental Factor Ontology (EFO) IDs): coronary heart disease

Score Details

Name: GRS27

Original Genome Build: NR
Number of Variants: 27

PGS Development Method: Genome-wide significant SNPs
PGS Development Details/Relevant Parameters:

Citation: Mega JL et al. Lancet (2015) | PGS Catalog Publication ID: PGP000003

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST000998
PubMed:
86,995 individuals
[ 22,233 cases, 64,762 controls]
European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000014 PSS000008 Mega JL et al. (2015) Reported Trait: Coronary heart disease HR: 1.21 [1.17 - 1.26] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000015 PSS000009 Mega JL et al. (2015) Reported Trait: Coronary heart disease HR: 1.14 [1.02 - 1.28] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000017 PSS000010 Tada H et al. (2015) Ext. Reported Trait: incident coronary heart disease cases HR: 1.2 [1.15 - 1.25] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000019 PSS000012 Abraham G et al. (2016) Ext. Reported Trait: Incident coronary artery disease HR: 1.21 [1.12 - 1.3]
PPM000021 PSS000011 Abraham G et al. (2016) Ext. Reported Trait: Incident coronary artery disease HR: 1.2 [1.07 - 1.26]

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 27,271 individuals
0.287 % Male samples
European
(Swedish)
MDC Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 8,749 individuals
[ 108 cases, 8,641 controls]
0.678 % Male samples
European JUPITER Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 6,978 individuals
[ 149 cases, 6,829 controls]
0.797 % Male samples
European ASCOT Primary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 2,878 individuals
[ 320 cases, 2,558 controls]
0.861 % Male samples
European CARE_b Secondary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 1,999 individuals
[ 229 cases, 1,770 controls]
0.775 % Male samples
European PROVEIT Secondary prevention cohorts
PSS000010 Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease. 23,595 individuals
[ 2,213 cases, 21,382 controls]
0.3802924348378894 % Male samples
European
(Swedish)
MDC Prospective study
PSS000011 The main outcome of interest was incident CHD event before age 75y. We used the definition of CHD as employed by the Framingham study, namely, one of • MI recognized, with diagnostic ECG (FHS event code #1) • MI recognized, without diagnostic ECG, with enzymes and history (#2) • MI recognized, without diagnostic ECG, with autopsy evidence (new event) (#3) • MI unrecognized, silent (#4) • MI unrecognized, not silent (#5) • Angina pectoris (AP), first episode only (#6) • Coronary insufficiency (CI), definite by both history and ECG (#7) • Questionable MI at exam 1 (#8) • Acute MI by autopsy, previously coded as 1 or 2 (#9) • Death, CHD sudden, with 1 hour (#21) • Death, CHD 1–23 hours, non sudden (#22) • Death, CHD 24-47 hours, non sudden (#23) • Death, CHD, 48 hours or more, non sudden (#24) 3,406 individuals
[ 587 cases, 2,819 controls]
45.0 % Male samples
European FHS FHS Original, FHS Offspring
PSS000012 Coronary heart disease (CHD) was defined as falling into any of the following categories: • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the direct or as a contributing cause of death or I20-I25 (ICD-10) /410-414 (ICD-9) as the underlying cause of death • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the main or secondary diagnosis at hospital discharge. • Coronary bypass surgery or coronary angioplasty at hospital discharge or identified from the Finnish registry of invasive cardiac procedures. 12,676 individuals
[ 757 cases, 11,919 controls]
46.0 % Male samples
European
(Finnish)
FINRISK FR92, FR97, FR02