Download PGS
(Variants and weights)

Polygenic Score (PGS) ID: PGS000023

Predicted Trait

Reported Trait: Type 1 diabetes
Mapped Trait(s) (Experimental Factor Ontology (EFO) IDs): type I diabetes mellitus

Score Details

Name: AA_GRS

Original Genome Build: NR
Number of Variants: 7

PGS Development Method: Genome-wide significant associations
PGS Development Details/Relevant Parameters:

Citation: Onengut-Gumuscu S et al. Diabetes Care (2019) | PGS Catalog Publication ID: PGP000013

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
PubMed: 30659077.0 101 individuals
[ 59 cases, 42 controls]
0.40594059405940597 % Male samples
African unspecified
PubMed: 30659077.0 368 individuals
[ 0 cases, 368 controls]
0.285 % Male samples
African unspecified
PubMed: 30659077.0 41 individuals
[ 41 cases, 0 controls]
0.415 % Male samples
African unspecified
PubMed: 30659077.0 801 individuals
[ 0 cases, 801 controls]
0.216 % Male samples
African unspecified
PubMed: 30659077.0 255 individuals
[ 255 cases, 0 controls]
0.439 % Male samples
African unspecified
PubMed: 30659077.0 1,262 individuals
[ 666 cases, 596 controls]
0.35657686212361334 % Male samples
African unspecified
PubMed: 30659077.0 659 individuals
[ 0 cases, 659 controls]
0.267 % Male samples
African unspecified
PubMed: 30659077.0 462 individuals
[ 0 cases, 462 controls]
0.346 % Male samples
African unspecified

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000045 PSS000030 Onengut-Gumuscu S et al. (2019) Reported Trait: Type 1 diabetes AUROC: 0.87 NOTE: Evaluated using cross-validation on training samples (20% heldout, 1000 iterations)
PPM000047 PSS000031 Onengut-Gumuscu S et al. (2019) Reported Trait: Type 1 diabetes AUROC: 0.779

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000030 3,949 individuals
[ 1,021 cases, 2,928 controls]
African unspecified BDC, CLEAR, GoKinD, NYCP, SEARCH, T1DGC, UAB
PSS000031 Cases are diagnosed with type 1 diabetes. 145 individuals
[ 61 cases, 54 controls]
African unspecified UOF