Download PGS
(Variants and weights)

Polygenic Score (PGS) ID: PGS000027

Predicted Trait

Reported Trait: Body Mass Index
Mapped Trait(s) (Experimental Factor Ontology (EFO) IDs): body mass index

Score Details

Name: GPS_BMI

Original Genome Build: hg19
Number of Variants: 2,100,302

PGS Development Method: LDpred
PGS Development Details/Relevant Parameters: ρ = 0.03; LD reference panel = 503 European samples from 1000 Genomes phase 3

Citation: Khera AV et al. Cell (2019) | PGS Catalog Publication ID: PGP000017

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST002783
PubMed: 25673413
236,781 individuals European
GWAS Catalog: GCST002783
PubMed: 25673413
887 individuals African American or Afro-Caribbean
GWAS Catalog: GCST002783
PubMed: 25673413
1,276 individuals Hispanic or Latin American
Score Development/Training
Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
119,951 individuals European UKB UKB Phase 1

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000054 PSS000037 Khera AV et al. (2019) Reported Trait: Body mass index β: 1.41 : 0.085264 First 10 genetic PCs Beta is in units of kg/m^2

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000037 288,016 individuals
45.0 % Male samples
European UKB