Publication: Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.

Information

PGS Catalog Publication (PGP) ID: PGP000003
PubMed ID: 25748612
doi: 10.1016/S0140-6736(14)61730-X

Publication Date: March 4, 2015

Journal: Lancet

Authors: Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield M, Devlin JJ, Nordio F, Hyde C, Cannon CP, Sacks F, Poulter N, Sever P, Ridker PM, Braunwald E, Melander O, Kathiresan S, Sabatine MS.

PGS Associated with PGP000003

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000014 PGS000010 (GRS27) PSS000008 Mega JL et al. (2015) Reported Trait: Coronary heart disease HR: 1.21 [1.17 - 1.26] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000015 PGS000010 (GRS27) PSS000009 Mega JL et al. (2015) Reported Trait: Coronary heart disease HR: 1.14 [1.02 - 1.28] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 27,271 individuals
0.287 % Male samples
European
(Swedish)
MDC Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 8,749 individuals
[ 108 cases, 8,641 controls]
0.678 % Male samples
European JUPITER Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 6,978 individuals
[ 149 cases, 6,829 controls]
0.797 % Male samples
European ASCOT Primary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 2,878 individuals
[ 320 cases, 2,558 controls]
0.861 % Male samples
European CARE_b Secondary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 1,999 individuals
[ 229 cases, 1,770 controls]
0.775 % Male samples
European PROVEIT Secondary prevention cohorts