Publication: Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.

Information

PGS Catalog Publication (PGP) ID: PGP000004
PubMed ID: 26392438
doi: 10.1093/eurheartj/ehv462

Publication Date: Sept. 20, 2015

Journal: Eur Heart J

Authors: Tada H, Melander O, Louie JZ, Catanese JJ, Rowland CM, Devlin JJ, Kathiresan S, Shiffman D.

PGS Associated with PGP000004

PGS Developed By This Study

External PGS Evaluated By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000016 PGS000011 (GRS50) PSS000010 Tada H et al. (2015) Reported Trait: incident coronary heart disease cases HR: 1.23 [1.18 - 1.28] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000017 PGS000010 (GRS27) PSS000010 Tada H et al. (2015) Ext. Reported Trait: incident coronary heart disease cases HR: 1.2 [1.15 - 1.25] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000010 Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease. 23,595 individuals
[ 2,213 cases, 21,382 controls]
0.3802924348378894 % Male samples
European
(Swedish)
MDC Prospective study