Publication: Genomic prediction of coronary heart disease.

Information

PGS Catalog Publication (PGP) ID: PGP000005
PubMed ID: 27655226
doi: 10.1093/eurheartj/ehw450

Publication Date: Sept. 21, 2016

Journal: Eur Heart J

Authors: Abraham G, Havulinna AS, Bhalala OG, Byars SG, De Livera AM, Yetukuri L, Tikkanen E, Perola M, Schunkert H, Sijbrands EJ, Palotie A, Samani NJ, Salomaa V, Ripatti S, Inouye M.

PGS Associated with PGP000005

PGS Developed By This Study

External PGS Evaluated By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000018 PGS000012 (GRS49K) PSS000012 Abraham G et al. (2016) Reported Trait: Incident coronary artery disease HR: 1.74 [1.61 - 1.86]
OR: 1.74 [1.61 - 1.89]
sex, sub-cohort, location (east/west), 5 genetic PCs Used only the 42,364 SNPs that were available in FINRISK
PPM000019 PGS000010 (GRS27) PSS000012 Abraham G et al. (2016) Ext. Reported Trait: Incident coronary artery disease HR: 1.21 [1.12 - 1.3]
PPM000020 PGS000012 (GRS49K) PSS000011 Abraham G et al. (2016) Reported Trait: Incident coronary artery disease HR: 1.28 [1.18 - 1.38]
OR: 1.28 [1.17 - 1.41]
sex, sub-cohort, 5 genetic PCs Used only the 46,773 SNPs that were available in FHS
PPM000021 PGS000010 (GRS27) PSS000011 Abraham G et al. (2016) Ext. Reported Trait: Incident coronary artery disease HR: 1.2 [1.07 - 1.26]

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000011 The main outcome of interest was incident CHD event before age 75y. We used the definition of CHD as employed by the Framingham study, namely, one of • MI recognized, with diagnostic ECG (FHS event code #1) • MI recognized, without diagnostic ECG, with enzymes and history (#2) • MI recognized, without diagnostic ECG, with autopsy evidence (new event) (#3) • MI unrecognized, silent (#4) • MI unrecognized, not silent (#5) • Angina pectoris (AP), first episode only (#6) • Coronary insufficiency (CI), definite by both history and ECG (#7) • Questionable MI at exam 1 (#8) • Acute MI by autopsy, previously coded as 1 or 2 (#9) • Death, CHD sudden, with 1 hour (#21) • Death, CHD 1–23 hours, non sudden (#22) • Death, CHD 24-47 hours, non sudden (#23) • Death, CHD, 48 hours or more, non sudden (#24) 3,406 individuals
[ 587 cases, 2,819 controls]
45.0 % Male samples
European FHS FHS Original, FHS Offspring
PSS000012 Coronary heart disease (CHD) was defined as falling into any of the following categories: • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the direct or as a contributing cause of death or I20-I25 (ICD-10) /410-414 (ICD-9) as the underlying cause of death • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the main or secondary diagnosis at hospital discharge. • Coronary bypass surgery or coronary angioplasty at hospital discharge or identified from the Finnish registry of invasive cardiac procedures. 12,676 individuals
[ 757 cases, 11,919 controls]
46.0 % Male samples
European
(Finnish)
FINRISK FR92, FR97, FR02