Publication: Longitudinal Analysis of Genetic Susceptibility and BMI Throughout Adult Life.

Information

PGS Catalog Publication (PGP) ID: PGP000021
PubMed ID: 29212779
doi: 10.2337/db17-1156

Publication Date: Dec. 6, 2017

Journal: Diabetes

Authors: Song M, Zheng Y, Qi L, Hu FB, Chan AT, Giovannucci EL.

PGS Associated with PGP000021

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000071 PGS000034 (GRS_BMI) PSS000048 Song M et al. (2017) Reported Trait: mean BMI difference β (per 10-allele increment): 0.54 [0.38 - 0.71]
PPM000072 PGS000034 (GRS_BMI) PSS000050 Song M et al. (2017) Reported Trait: mean BMI difference β (per 10-allele increment): 0.17 [0.03 - 0.31]
PPM000073 PGS000034 (GRS_BMI) PSS000051 Song M et al. (2017) Reported Trait: mean BMI difference β (per 10-allele increment): -0.22 [-0.39 - -0.05]
PPM000074 PGS000034 (GRS_BMI) PSS000049 Song M et al. (2017) Reported Trait: mean BMI difference β (per 10-allele increment): 0.6 [0.42 - 0.77]
PPM000075 PGS000034 (GRS_BMI) PSS000052 Song M et al. (2017) Reported Trait: mean BMI difference β (per 10-allele increment): 0.07 [-0.04 - 0.19]
PPM000076 PGS000034 (GRS_BMI) PSS000045 Song M et al. (2017) Reported Trait: mean BMI difference β (per 10-allele increment): 0.23 [0.02 - 0.44]
PPM000077 PGS000034 (GRS_BMI) PSS000046 Song M et al. (2017) Reported Trait: mean BMI difference β (per 10-allele increment): -0.1 [-0.29 - 0.09]
PPM000078 PGS000034 (GRS_BMI) PSS000047 Song M et al. (2017) Reported Trait: mean BMI difference β (per 10-allele increment): -0.01 [-0.16 - 0.14]

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000045 BMI difference between ages 21 and 45 1,699 individuals
100.0 % Male samples
European HPFS
PSS000046 BMI difference between ages 45 and 65 1,634 individuals
100.0 % Male samples
European HPFS
PSS000047 BMI difference between ages 65 and 80 2,020 individuals
100.0 % Male samples
European HPFS
PSS000048 BMI difference between ages 18 and 45 5,956 individuals
0.0 % Male samples
European NHS
PSS000049 BMI difference between age 18 and Menopause 6,705 individuals
0.0 % Male samples
European NHS
PSS000050 BMI difference between ages 45 and 65 5,640 individuals
0.0 % Male samples
European NHS
PSS000051 BMI difference between ages 65 and 80 2,942 individuals
0.0 % Male samples
European NHS
PSS000052 BMI difference between Menopause and age 65 6,436 individuals
0.0 % Male samples
European NHS