Publication: Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine.

Information

PGS Catalog Publication (PGP) ID: PGP000024
PubMed ID: 31322649
doi: 10.1210/er.2019-00088

Publication Date: Dec. 1, 2019

Journal: Endocr Rev

Authors: Udler MS, McCarthy MI, Florez JC, Mahajan A.

PGS Associated with PGP000024

External PGS Evaluated By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000080 PGS000036 (gePS_T2D) PSS000054 Udler MS et al. (2019) Ext. Reported Trait: Type 2 diabetes AUROC: 0.66 genotyping array, first 6 PCs of ancestry
PPM000081 PGS000036 (gePS_T2D) PSS000054 Udler MS et al. (2019) Ext. Reported Trait: Type 2 diabetes AUROC: 0.73 age, sex, genotyping array, first 6 PCs of ancestry

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000054 Prevalent T2D status was defined using self-reported medical history and medication 324,870 individuals
[ 13,480 cases, 311,390 controls]
European UKB