Polygenic Score (PGS) ID: PGS003724

Predicted Trait
Reported Trait Intelligence quotient
Mapped Trait(s) intelligence (EFO_0004337)
Additional Trait Information UKB Verbal Numeric Reasoning (VNR) task
Released in PGS Catalog: April 28, 2023
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Score Details

Score Construction
PGS Name IQ
Development Method
Name SBLUP
Parameters MAF<0.01, INFO<0.3, causal variant p<1
Variants
Original Genome Build GRCh37
Number of Variants 6,683,248
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000465
Citation (link to publication) Hatoum AS et al. Biol Psychiatry (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
216,381 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90179114
Europe PMC: 36150907
 216,381 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018418 PSS010959|
European Ancestry|
916 individuals
 PGP000465 |
Hatoum AS et al. Biol Psychiatry (2022)
 Reported Trait: Intelligence quotient β: 0.149 — R²: 0.121 PCs1-10, genotyping batch, cEF PGS cEF and IQ were genetically correlated (0.61) so were used as covariates in the PGS prediction model.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010959 — — 916 individuals — European — COL_Twin —