| Predicted Trait | |
| Reported Trait | Addiction risk factors |
| Mapped Trait(s) | substance-related disorder (MONDO_0002494) |
| Additional Trait Information | meta-analysis of Cannabis Use Disorder, problematic Tobacco use, problematic alcohol use, and opioid use disorder |
| Score Construction | |
| PGS Name | PRSaddiction-rf |
| Development Method | |
| Name | PRS-CS |
| Parameters | Whole genome score using PRS-cs Auto. Used 1000K genome panel. Scores are poseterior probability weights per snp. |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 584,753 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000490 |
| Citation (link to publication) | Hatoum AS et al. Nat Ment Health (2023) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 1,025,550 individuals (100%) |
| PGS Evaluation | European: 100% 1 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
| — | 1,025,550 individuals | European | NR |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM018660 | PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Cocaine Use Disorder | OR: 1.569 β: 0.451 (0.058) |
— | — | First 10 principal components, age, and sex | — |
| PPM018657 | PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Tobacco Use Disorder | OR: 1.643 β: 0.497 (0.054) |
— | — | First 10 principal components, age, and sex | — |
| PPM018658 | PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Opioid Use Disorder | OR: 1.728 β: 0.5471 (0.062) |
— | — | First 10 principal components, age, and sex | — |
| PPM018661 | PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Any Addiction | OR: 1.633 β: 0.49 (0.052) |
— | — | First 10 principal components, age, and sex | — |
| PPM018663 | PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Polysubstance use (2 or more) vs. Single substance use | OR: 1.445 β: 0.368 (0.082) |
— | — | First 10 principal components, age, and sex | — |
| PPM018656 | PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Alcohol Use Disorder | OR: 1.57 β: 0.451 (0.052) |
— | — | First 10 principal components, age, and sex | — |
| PPM018659 | PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Cannabis Use Disorder | OR: 1.413 β: 0.3455 (0.057) |
— | — | First 10 principal components, age, and sex | — |
| PPM018662 | PSS011056| European Ancestry| 1,986 individuals |
PGP000490 | Hatoum AS et al. Nat Ment Health (2023) |
Reported Trait: Polysubstance use (2 or more) vs. no polysubstance use | OR: 1.721 β: 0.5427 (0.055) |
— | — | First 10 principal components, age, and sex | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS011056 | — | — | 1,986 individuals | — | European | — | Yale-Penn | — |