Polygenic Score (PGS) ID: PGS003894

Predicted Trait
Reported Trait Hip circumference
Mapped Trait(s) hip circumference (EFO_0005093)
Additional Trait Information http://ipgs.mit.edu/tanigawakellis2023/INI49
Released in PGS Catalog: Nov. 1, 2023
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Score Details

Score Construction
PGS Name INI49
Development Method
Name snpnet
Parameters inclusive PGS
Variants
Original Genome Build GRCh37
Number of Variants 32,756
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000502
Citation (link to publication) Tanigawa Y et al. AJHG (2023)
Ancestry Distribution
Score Development/Training
Multi-ancestry (including European): 100%
  • European
  • South Asian
  • African
  • Additional Diverse Ancestries
324,569 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
Multi-ancestry (excluding European): 20%
  • East Asian
  • Additional Diverse Ancestries
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 324,569 individuals European, South Asian, African unspecified, Other admixed ancestry UKB — — — European, South Asian, African unspecified, Other admixed ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018789 PSS011148|
European Ancestry|
67,624 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Hip circumference — — R²: 0.10669 [0.1023, 0.11109]
PGS R2 (no covariates): 0.10277 [0.09844, 0.1071]
Incremental R2 (full-covars): 0.10175		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM018790 PSS011103|
European Ancestry|
2,885 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Hip circumference — — R²: 0.10294 [0.08199, 0.12388]
PGS R2 (no covariates): 0.1049 [0.0838, 0.126]
Incremental R2 (full-covars): 0.102		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM018791 PSS011117|
South Asian Ancestry|
1,473 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Hip circumference — — R²: 0.0983 [0.06963, 0.12697]
Incremental R2 (full-covars): 0.07962
PGS R2 (no covariates): 0.08534 [0.05824, 0.11244]		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM018792 PSS011160|
African Ancestry|
1,195 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Hip circumference — — R²: 0.01885 [0.00373, 0.03396]
PGS R2 (no covariates): 0.01479 [0.00134, 0.02824]
Incremental R2 (full-covars): 0.01389		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM018793 PSS011174|
Multi-ancestry (excluding European)|
7,971 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Hip circumference — — R²: 0.12987 [0.11614, 0.1436]
PGS R2 (no covariates): 0.09021 [0.07824, 0.10217]
Incremental R2 (full-covars): 0.07349		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011174 — — 7,971 individuals — East Asian, Other admixed ancestry East Asian, Other admixed ancestry UKB —
PSS011148 — — 67,624 individuals — European
(white British ancestry)		 — UKB —
PSS011117 — — 1,473 individuals — South Asian — UKB —
PSS011160 — — 1,195 individuals — African unspecified — UKB —
PSS011103 — — 2,885 individuals — European
(non-white British ancestry)		 — UKB —