Polygenic Score (PGS) ID: PGS004006

Predicted Trait
Reported Trait Gout
Mapped Trait(s) gout (EFO_0004274)
Released in PGS Catalog: Dec. 19, 2023
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name lassosum.auto.GCST008972.Gout
Development Method
Name lassosum.auto
Parameters s0.2,lambda0.00335981828628378
Variants
Original Genome Build GRCh38
Number of Variants 19,101
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000517
Citation (link to publication) Monti M R et al. medRxiv (2023) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
6,704 individuals (100%)
PGS Evaluation
European: 66.7%
South Asian: 33.3%
6 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 6,704 individuals European UKB — — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019901 PSS011217|
European Ancestry|
199,274 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Gout OR: 1.49846
β: 0.40444		 AUROC: 0.61 — 0 beta = log(or)/sd_pgs
PPM019902 PSS011229|
European Ancestry|
257,781 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Gout OR: 1.5767
β: 0.45534		 AUROC: 0.62 — 0 beta = log(or)/sd_pgs
PPM019904 PSS011240|
South Asian Ancestry|
44,057 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Gout OR: 1.75393
β: 0.56186		 AUROC: 0.66 — 0 beta = log(or)/sd_pgs
PPM019905 PSS011256|
European Ancestry|
66,865 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Gout OR: 1.67964
β: 0.51858		 AUROC: 0.64 — 0 beta = log(or)/sd_pgs
PPM019907 PSS011284|
South Asian Ancestry|
9,326 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Gout OR: 1.48465
β: 0.39518		 AUROC: 0.61 — 0 beta = log(or)/sd_pgs
PPM019909 PSS011270|
European Ancestry|
90,274 individuals
 PGP000517 |
Monti M R et al. medRxiv (2023)
|Pre		 Reported Trait: Gout OR: 1.89517
β: 0.63931		 AUROC: 0.67 — 0 beta = log(or)/sd_pgs

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011240 — —
[
  • 282 cases
  • , 43,775 controls
]
 — South Asian — G&H —
PSS011217 — —
[
  • 10,646 cases
  • , 188,628 controls
]
 — European — EB —
PSS011284 — —
[
  • 206 cases
  • , 9,120 controls
]
 — South Asian — UKB —
PSS011256 — —
[
  • 1,318 cases
  • , 65,547 controls
]
 — European — HUNT —
PSS011229 M13_GOUT, ICD10: M10, ICD9: 2740 —
[
  • 8,759 cases
  • , 249,022 controls
]
 — European — FinnGen —
PSS011270 — —
[
  • 1,676 cases
  • , 88,598 controls
]
 — European — UKB —