Polygenic Score (PGS) ID: PGS004222

Predicted Trait
Reported Trait Gout
Mapped Trait(s) gout (EFO_0004274)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name GRS13_gout
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 13
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000522
Citation (link to publication) Wu Q et al. J Psychosom Res (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
71,473 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST012338
Europe PMC: 33832965
 71,473 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020157 PSS011298|
Multi-ancestry (including European)|
403,630 individuals
 PGP000522 |
Wu Q et al. J Psychosom Res (2023)
 Reported Trait: Incident gout — — p (interaction between PRS and sleep pattern): 0.043 Age, sex, race, Townsend deprivation index (TDI), body mass index (BMI), smoking and drinking status, history of hypertension and diabetes, uric acid, total cholesterol, estimated glomerular filtration rate (eGFR) levels, the use of diuretics medications —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011298 — — 382,477 individuals — European — UKB —
PSS011298 — — 21,153 individuals — Not reported — UKB —