Polygenic Score (PGS) ID: PGS004230

Predicted Trait
Reported Trait Impulsivity
Mapped Trait(s) behavioural disinhibition measurement (EFO_0006946)
Additional Trait Information combining 11 PRSs for ADHD, AUDIT-total, smoking initiation, smoking cessation, cigarettes per day, BMI, years of education, neuroticims, externalizing, general risk tolerance.
Released in PGS Catalog: Dec. 15, 2023
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name Impulsivity_combined
Development Method
Name lassosum, linear regression
Parameters Lassosum against hg19 with effective sample sizes based on GWASs for each of the 10 additional traits and optimized prediction for each respective trait; the final PRS score for the target trait was obtained by taking a linear regression combining these 11 PRSs that maximized adjusted R2 with respect to the target trait.
Variants
Original Genome Build hg19
Number of Variants 3,465,707
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000528
Citation (link to publication) Deng WQ et al. Genes Brain Behav (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 99.8%
African: 0.1%
East Asian: 0.02%
Hispanic or Latin American: 0.01%
Not Reported: 0%
8,875,574 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007322
Europe PMC: 30643258
 939,908 individuals European NR
GWAS Catalog: GCST90061435
Europe PMC: 34446935
 1,492,085 individuals European NR
GWAS Catalog: GCST006476
Europe PMC: 29942085
 449,484 individuals European NR
GWAS Catalog: GCST90105038
Europe PMC: 35361970
 3,037,499 individuals European NR
GWAS Catalog: GCST007459
Europe PMC: 30643251
 377,334 individuals European NR
GWAS Catalog: GCST007460
Europe PMC: 30643251
 547,219 individuals European NR
GWAS Catalog: GCST007474
Europe PMC: 30643251
 1,232,091 individuals European NR
GWAS Catalog: GCST006717
Europe PMC: 30336701
 121,604 individuals European NR
GWAS Catalog: GCST007543
Europe PMC: 30478444
 144 individuals Not reported NR
GWAS Catalog: GCST007543
Europe PMC: 30478444
 53,293 individuals European NR
GWAS Catalog: GCST007543
Europe PMC: 30478444
 1,937 individuals East Asian NR
GWAS Catalog: GCST011179
Europe PMC: 33096046
 9,745 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST011179
Europe PMC: 33096046
 374,287 individuals European NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 236,781 individuals European NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 887 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST002783
Europe PMC: 25673413
 1,276 individuals Hispanic or Latin American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020224 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Negative urgency β: 0.172 — R²: 0.0381
adjusted R2 only by the PRS: 0.0246		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020225 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Lack of premeditation β: 0.167 — R²: 0.0217
adjusted R2 only by the PRS: 0.0211		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020226 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Delayed reward discounting (small magnitude rewards) β: 0.166 — R²: 0.0811
adjusted R2 only by the PRS: 0.0212 %		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020228 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Delayed reward discounting (large magnitude rewards) β: 0.151 — R²: 0.1294
adjusted R2 only by the PRS: 0.0176		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait
PPM020227 PSS011308|
European Ancestry|
1,534 individuals
 PGP000528 |
Deng WQ et al. Genes Brain Behav (2023)
 Reported Trait: Delayed reward discounting (medium magnitude rewards) β: 0.161 — R²: 0.1081
adjusted R2 only by the PRS: 0.0195 %		 first 10 genetic PC, sex, age, income, an indicator for genotying array version. beta between standardized PRS and standardized trait

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011308 — — 1,534 individuals,
43.0 % Male samples
 Mean = 34.9 years
Sd = 14.2 years		 European — NR Existing research registry at St. Joseph's Healthcare, Hamilton