Polygenic Score (PGS) ID: PGS004236

Predicted Trait
Reported Trait Hypertension
Mapped Trait(s) hypertension (EFO_0000537)
Released in PGS Catalog: Dec. 15, 2023
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name HTN_Unweighted_PRSsum
Development Method
Name PRSsum
Parameters sum of DBP, SBP and HTN (CV-PRS)
Variants
Original Genome Build GRCh38
Number of Variants 398,805
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000531
Citation (link to publication) Kurniansyah N et al. Nat Commun (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 41.5%
  • African
  • Hispanic or Latin American
  • European
  • South Asian
  • Additional Asian Ancestries
  • Greater Middle Eastern
  • East Asian
European: 41.3%
African: 11.7%
Hispanic or Latin American: 4.2%
Additional Asian Ancestries: 0.9%
Additional Diverse Ancestries: 0.5%
1,089,676 individuals (100%)
Score Development/Training
Hispanic or Latin American: 40.6%
African: 27.2%
European: 24.3%
Not Reported: 6.5%
Additional Asian Ancestries: 1.5%
10,314 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • African
  • Hispanic or Latin American
  • Additional Asian Ancestries
  • European
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007270
Europe PMC: 30578418
 225,112 individuals European MVP
GWAS Catalog: GCST007270
Europe PMC: 30578418
 63,490 individuals African unspecified MVP
GWAS Catalog: GCST007270
Europe PMC: 30578418
 22,802 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST007270
Europe PMC: 30578418
 4,792 individuals Asian unspecified MVP
GWAS Catalog: GCST007270
Europe PMC: 30578418
 2,695 individuals Native American MVP
GWAS Catalog: GCST007271
Europe PMC: 30578418
 225,112 individuals European MVP
GWAS Catalog: GCST007271
Europe PMC: 30578418
 63,490 individuals African unspecified MVP
GWAS Catalog: GCST007271
Europe PMC: 30578418
 22,802 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST007271
Europe PMC: 30578418
 4,792 individuals Asian unspecified MVP
GWAS Catalog: GCST007271
Europe PMC: 30578418
 2,695 individuals Native American MVP
[
  • 126,196 cases
  • , 325,698 controls
]
 African unspecified,Hispanic or Latin American,European,South Asian,Central Asian,Greater Middle Eastern (Middle Eastern, North African or Persian),East Asian UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 2,803 individuals,
33.5 % Male samples
 African American or Afro-Caribbean BioMe — Mean = 55.9 years
Sd = 12.5 years		 — — —
— 151 individuals,
44.4 % Male samples
 Asian unspecified BioMe — Mean = 53.14 years
Sd = 13.52 years		 — — —
— 2,506 individuals,
52.2 % Male samples
 European BioMe — Mean = 60.42 years
Sd = 13.96 years		 — — —
— 4,187 individuals,
37.5 % Male samples
 Hispanic or Latin American BioMe — Mean = 57.72 years
Sd = 13.18 years		 — — —
— 667 individuals,
57.9 % Male samples
 Not reported BioMe — Mean = 57.51 years
Sd = 13.1 years		 — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020255 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: Prevelant hypertension OR: 2.1 [1.99, 2.21] AUROC: 0.764 [0.751, 0.777] — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components PRSsum based on selected CV-PRS (which summed the CV-PRS from the three phenotypes).
PPM020256 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: New-onset hypertension (normotensive) OR: 1.72 [1.55, 1.91] AUROC: 0.656 — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components PRSsum based on selected CV-PRS (which summed the CV-PRS from the three phenotypes).
PPM020257 PSS011312|
Multi-ancestry (including European)|
39,035 individuals
 PGP000531 |
Kurniansyah N et al. Nat Commun (2022)
 Reported Trait: New-onset hypertension (elevated) OR: 1.48 [1.27, 1.71] AUROC: 0.582 — sex, age, age2, study site, race/ethnic background, smoking status, BMI, and 11 ancestral principal components PRSsum based on selected CV-PRS (which summed the CV-PRS from the three phenotypes).

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011312 — — 8,822 individuals,
31.9 % Male samples
 — African American or Afro-Caribbean — 6 cohorts
  • ARIC
  • ,CHS
  • ,GENOA
  • ,JHS
  • ,MESA
  • ,WHI
 —
PSS011312 — — 6,718 individuals,
38.0 % Male samples
 — Hispanic or Latin American — 6 cohorts
  • CHS
  • ,FHS
  • ,HCHS
  • ,MESA
  • ,SOL
  • ,WHI
 —
PSS011312 — — 794 individuals,
37.9 % Male samples
 — Asian unspecified — MESA, WHI —
PSS011312 — — 22,701 individuals,
27.8 % Male samples
 — European — ARIC, CHS, FHS, MESA, WHI —