Polygenic Score (PGS) ID: PGS004251

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: Dec. 15, 2023
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Score Details

Score Construction
PGS Name PRS125_prostate
Development Method
Name PRSice-2
Parameters p = 5E-8, r2 = 0.1
Variants
Original Genome Build GRCh37
Number of Variants 125
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000542
Citation (link to publication) Kim ES et al. NPJ Precis Oncol (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 95.1%
Hispanic or Latin American: 1.9%
East Asian: 1.7%
African: 1.2%
186,632 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006085
Europe PMC: 29892016
 140,254 individuals European NR
GWAS Catalog: GCST002944
Europe PMC: 26034056
 37,272 individuals European NR
GWAS Catalog: GCST002944
Europe PMC: 26034056
 2,251 individuals African American or Afro-Caribbean NR
GWAS Catalog: GCST002944
Europe PMC: 26034056
 3,226 individuals East Asian NR
GWAS Catalog: GCST002944
Europe PMC: 26034056
 3,629 individuals Hispanic or Latin American NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020315 PSS011329|
European Ancestry|
115,207 individuals
 PGP000542 |
Kim ES et al. NPJ Precis Oncol (2023)
 Reported Trait: Prostate cancer HR: 1.78 [1.72, 1.85] — — first 10 genetic principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011329 — — 115,207 individuals,
100.0 % Male samples
 — European
(British)		 — UKB —