Polygenic Score (PGS) ID: PGS004318

Predicted Trait
Reported Trait Dementia
Mapped Trait(s) dementia (MONDO_0001627)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
PGS Name PRS29_dementia
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 29
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000548
Citation (link to publication) Feng J et al. BMC Geriatr (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 97.8%
Not Reported: 2.2%
223,492 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • African
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007511
Europe PMC: 30820047
 63,926 individuals European NR
GWAS Catalog: GCST002245
Europe PMC: 24162737
 55,134 individuals European NR
GWAS Catalog: GCST001025
Europe PMC: 21460840
 20,373 individuals European
(France)		 NR
GWAS Catalog: GCST002593
Europe PMC: 25188341
 4,914 individuals Not reported NR
GWAS Catalog: GCST007319
Europe PMC: 30617256
 79,145 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020398 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Alzheimer's disease — — Hazard ratio (HR, high vs low PRS tertile): 4.11 [3.71, 4.54] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020399 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Vascular dementia — — Hazard ratio (HR, high vs low PRS tertile): 2.43 [2.15, 2.75] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020400 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Dementia with high laxatives exposure — — Hazard ratio (HR, high laxative use and PRS in top tertile vs no laxative use and PRS in bottom tertile): 4.09 [3.48, 4.81] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020401 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Alzheimer's disease with high laxatives exposure — — Hazard ratio (HR, high laxative use and PRS in top tertile vs no laxative use and PRS in bottom tertile): 4.62 [3.56, 6.0] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020402 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Vascular dementia with high laxatives exposure — — Hazard ratio (HR, high laxative use and PRS in top tertile vs no laxative use and PRS in bottom tertile): 3.27 [2.37, 4.51] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —
PPM020397 PSS011350|
Multi-ancestry (including European)|
57,688 individuals
 PGP000548 |
Feng J et al. BMC Geriatr (2023)
 Reported Trait: Dementia — — Hazard ratio (HR, high vs low PRS tertile): 2.76 [2.6, 2.93] Sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, and constipation —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011350 — — 53,447 individuals — European — UKB Mean age of full combined ancestry cohort = 58 years
PSS011350 — — 1,118 individuals — African unspecified — UKB Mean age of full combined ancestry cohort = 58 years
PSS011350 — — 3,123 individuals — Asian unspecified, Not reported — UKB Mean age of full combined ancestry cohort = 58 years