PGS Sample Set (PSS): PSS000011

Phenotype The main outcome of interest was incident CHD event before age 75y. We used the definition of CHD as employed by the Framingham study, namely, one of • MI recognized, with diagnostic ECG (FHS event code #1) • MI recognized, without diagnostic ECG, with enzymes and history (#2) • MI recognized, without diagnostic ECG, with autopsy evidence (new event) (#3) • MI unrecognized, silent (#4) • MI unrecognized, not silent (#5) • Angina pectoris (AP), first episode only (#6) • Coronary insufficiency (CI), definite by both history and ECG (#7) • Questionable MI at exam 1 (#8) • Acute MI by autopsy, previously coded as 1 or 2 (#9) • Death, CHD sudden, with 1 hour (#21) • Death, CHD 1–23 hours, non sudden (#22) • Death, CHD 24-47 hours, non sudden (#23) • Death, CHD, 48 hours or more, non sudden (#24)
Sample Ancestry European

Sample Numbers

Total number
3,406 individuals
Detailed numbers
587 cases (17.23%)
2,819 controls
45.0% Male samples
Number of Cohort(s) 1
Sample distribution
ControlsCases
Sample gender distribution
% Female% Male

Cohort(s)

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Cohort Short Name
Cohort Full Name
Previous/other/additional names (e.g. sub-cohorts)
FHSFramingham Heart Study
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Additional information

FHS Original, FHS Offspring