Predicted Trait | |
Reported Trait | Basophil percentage of white cells |
Mapped Trait(s) | basophil percentage of leukocytes (EFO_0007992) |
Additional Trait Information | BASO% |
Score Construction | |
PGS Name | baso_p |
Development Method | |
Name | Regularized Regression (Elastic Net) |
Parameters | Bi-allelic variants (MAF > 0.01, INFO > 0.4, missingness rate < 0.1) with LD thinning (r2 threshold = 0.5) |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 5,248 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000051 |
Citation (link to publication) | Xu Y et al. Cell Genom (2022) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
— | 404,532 individuals, 46.0 % Male samples |
European | UKB |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 323,626 individuals, 46.0 % Male samples |
European | UKB | — | Mean = 57.23 years Range = [38.87, 72.44] years |
— | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM000210 | PSS000154| European Ancestry| 80,906 individuals |
PGP000051 | Xu Y et al. Cell Genom (2022) |
Reported Trait: Basophil percentage of white cells | — | — | Pearson correlation coefficent (r): 0.18838 | age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) | UKB Testing Set - these samples were held out from Score Development (regression training) but overlap with the samples used for variant selection (GWAS) |
PPM000211 | PSS000128| European Ancestry| 40,133 individuals |
PGP000051 | Xu Y et al. Cell Genom (2022) |
Reported Trait: Basophil percentage of white cells | — | — | Pearson correlation coefficent (r): 0.17123 | age, sex, 10 PCs of ancestry, lifestyle factors (diet, smoking, alcohol consumption), technical covariates (the time between venepuncture and full blood cell analysis, seasonal effects, centre of sample collection, time dependent drift of equipment, systematic differences in equipment) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000128 | — | — | 40,133 individuals, 50.0 % Male samples |
Mean = 43.92 years Range = [18.0, 76.4] years |
European | — | INTERVAL | — |
PSS000154 | — | — | 80,906 individuals, 46.0 % Male samples |
Mean = 57.2 years Range = [40.18, 72.91] years |
European | — | UKB | — |