Polygenic Score (PGS) ID: PGS000178

Predicted Trait
Reported Trait Monocyte percentage of white cells
Mapped Trait(s) monocyte percentage of leukocytes (EFO_0007989)
Additional Trait Information MONO%
Released in PGS Catalog: April 29, 2020
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name mono_p
Development Method
Name Genome-wide significant variants
Parameters Conditionally independent GWAS associations
Variants
Original Genome Build GRCh37
Number of Variants 549
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000078
Citation (link to publication) Vuckovic D et al. Cell (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
408,112 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
408,112 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000534 PSS000291|
European Ancestry|
39,260 individuals
 PGP000078 |
Vuckovic D et al. Cell (2020)
 Reported Trait: Monocyte percentage of white cells — — R²: 0.14461 sex, age, 10 genetic PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000291 — — 39,260 individuals — European — INTERVAL —