Polygenic Score (PGS) ID: PGS000206

Predicted Trait
Reported Trait Risk-taking tendency (4-domain principal component model)
Mapped Trait(s) risk-taking behaviour (EFO_0008579)
Released in PGS Catalog: July 1, 2020
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Score Details

Score Construction
PGS Name RISK_PC_FT12
Development Method
Name PRS-CS
Parameters LD-reference panel = 1000G Europeans; SNPs selected to overlap HapMap3 and FinnTwin12 Study
Variants
Original Genome Build NR
Number of Variants 1,098,765
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000084
Citation (link to publication) Barr PB et al. Transl Psychiatry (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
315,894 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007323
Europe PMC: 30643258
 315,894 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000630 PSS000340|
European Ancestry|
1,251 individuals
 PGP000084 |
Barr PB et al. Transl Psychiatry (2020)
 Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.1 (0.02) — ΔR-squared (vs. covariates alone): 0.02273 sex, age of last observation, 10 Genetic PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000340 — — 1,251 individuals,
45.6 % Male samples
 Mean = 21.9 years
Sd = 0.77 years
Range = [21.0, 26.0] years		 European
(Finnish)		 — FinnTwin12 Twin Study