| Predicted Trait | |
| Reported Trait | Coronary heart disease |
| Mapped Trait(s) | coronary artery disease (EFO_0001645) |
| Score Construction | |
| PGS Name | PRS_CHD |
| Development Method | |
| Name | LDpred |
| Parameters | ρ = 0.003; LD radius = 4000; LD reference panel = 2,690 Finnish individuals [autosomal variants only... ]Show more |
| Variants | |
| Original Genome Build | hg19 |
| Number of Variants | 6,423,165 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000100 |
| Citation (link to publication) | Mars N et al. Nat Med (2020) |
Study Identifiers
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Sample Numbers
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Sample Ancestry
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Cohort(s)
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|---|---|---|---|
GWAS Catalog: GCST008370 Europe PMC: 30104761 | 408,458 individuals | European | UKB |
Study Identifiers
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Sample Numbers
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Sample Ancestry
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Cohort(s)
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Phenotype Definitions & Methods
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Age of Study Participants
|
Participant Follow-up Time
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Additional Ancestry Description
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Additional Sample/Cohort Information
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|---|---|---|---|---|---|---|---|---|
| — | 21,813 individuals, 47.3 % Male samples | European (Finnish) | FINRISK | National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis o... f the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first. Disease endpoints are defined in Table S9.Show more | Mean (Age At Baseline) = 48.0 years | — | — | Used to select optimal threshold of ρ for all subsequent analyses. FINRISK surveys from 1992, 1997, 2002 and 2007 |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000886 | PSS000445| European Ancestry| 135,300 individuals | PGP000100 | Mars N et al. Nat Med (2020) | Reported Trait: Coronary heart disease (incident and prevalent cases) | HR: 1.31 [1.29, 1.33] | — | — | genotyping array/batch, 10 ancestry PCs, stratified by sex | — |
| PPM000891 | PSS000440| European Ancestry| 20,165 individuals | PGP000100 | Mars N et al. Nat Med (2020) | Reported Trait: Incident coronary heart disease | HR: 1.25 [1.18, 1.32] | C-index: 0.832 | — | age, sex, FINRISK cohort, genotyping array/batch, 10 ancestry PCs | 10-year risk |
| PPM000896 | PSS000440| European Ancestry| 20,165 individuals | PGP000100 | Mars N et al. Nat Med (2020) | Reported Trait: Incident coronary heart disease | — | C-index: 0.82 | — | ASCVD risk calculator(age, sex, total cholesterol, HDL, SBP, blood-pressure-lowering medication, dia... betes and smoking status), FINRISK cohort, genotyping array/batch, 10 ancestry PCsShow more | 10-year risk |
| PPM017092 | PSS010120| European Ancestry| 4,218 individuals | PGP000433 | de La Harpe R et al. Eur J Prev Cardiol (2023) |Ext. | Reported Trait: Atherosclerotic cardiovascular disease (incident and prevalent) | OR: 1.33 [1.2, 1.49] | AUROC: 0.765 [0.74, 0.79] | — | sex, age | — |
| PPM017093 | PSS010122| European Ancestry| 4,218 individuals | PGP000433 | de La Harpe R et al. Eur J Prev Cardiol (2023) |Ext. | Reported Trait: Coronary heart disease (incident and prevalent) | OR: 1.59 [1.42, 1.77] | AUROC: 0.779 [0.756, 0.803] | — | sex, age | — |
| PPM017094 | PSS010119| European Ancestry| 3,383 individuals | PGP000433 | de La Harpe R et al. Eur J Prev Cardiol (2023) |Ext. | Reported Trait: Incident atherosclerotic cardiovascular disease | HR: 1.29 [1.12, 1.47] | — | — | sex, age, 10 principal components | — |
| PPM017095 | PSS010121| European Ancestry| 3,383 individuals | PGP000433 | de La Harpe R et al. Eur J Prev Cardiol (2023) |Ext. | Reported Trait: Incident coronary heart disease | HR: 1.57 [1.4, 1.77] | — | — | sex, age, 10 principal components | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
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Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS000440 | Coronary heart disease was defined as Myocardial infarction|Myocardial infarction, strict|Complicati... ons following myocardial infarction|Prior myocardial infactrion|Angina pectoris|Other coronary atherosclerosis|Coronary artery bypass graft**|Coronary angioplasty**. ICD9/10 codes are listed in Table S9. National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first.Show more | — | [ ,
47.3 % Male samples | Mean (Age At Baseline) = 48.0 years | European (Finnish) | — | FINRISK | FINRISK surveys from 1992, 1997, 2002 and 2007 |
| PSS000445 | Coronary heart disease was defined as Myocardial infarction|Myocardial infarction, strict|Complicati... ons following myocardial infarction|Prior myocardial infactrion|Angina pectoris|Other coronary atherosclerosis|Coronary artery bypass graft**|Coronary angioplasty**. ICD9/10 codes are listed in Table S9. National registries were used to assess disease incidence. Follow-up ended at first-ever diagnosis of the disease of interest, death or at the end of follow-up on December 31, 2018, whichever came first.Show more | — | [ ,
43.7 % Male samples | Mean (Age At Baseline) = 59.2 years Sd = 16.6 years | European (Finnish) | — | FinnGen | — |
| PSS010119 | Atherosclerotic cardiovacular disease (ASCVD), comprising non-fatal acute myocardial infarction, dea... th of cardiovascular origin (comprising sudden death, ischemic death) and fatal and non-fatal ischaemic stroke (including transient ischaemic attack) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036Show more | Median = [10.7, 14.6] years | [ ,
45.0 % Male samples | Mean = 52.3 years | European | — | CoLaus | right censored was death or latest evidence of good health, participant with statine therapy at base... line were excludedShow more |
| PSS010120 | Atherosclerotic cardiovacular disease (ASCVD), comprising non-fatal acute myocardial infarction, dea... th of cardiovascular origin (comprising sudden death, ischemic death) and fatal and non-fatal ischaemic stroke (including transient ischaemic attack) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036Show more | Median = [10.6, 14.6] years | [ ,
47.0 % Male samples | Mean = 53.4 years | European | — | CoLaus | right censored was death or latest evidence of good health |
| PSS010121 | Coronary artery disease (CAD), ccomprising either non-fatal myocardial infarction, death from corona... ry heart disease or symptomatic stable angina followed by a revascularization procedure, either by percutaneous coronary intervention (PCI), or by coronary artery bypass grafting (CABG) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036Show more | Median = [10.7, 14.6] years | [ ,
45.0 % Male samples | Mean = 52.3 years | European | — | CoLaus | right censored was death or latest evidence of good health, participant with statine therapy at base... line were excludedShow more |
| PSS010122 | Coronary artery disease (CAD), ccomprising either non-fatal myocardial infarction, death from corona... ry heart disease or symptomatic stable angina followed by a revascularization procedure, either by percutaneous coronary intervention (PCI), or by coronary artery bypass grafting (CABG) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036Show more | Median = [10.6, 14.6] years | [ ,
47.0 % Male samples | Mean = 53.4 years | European | — | CoLaus | right censored was death or latest evidence of good health |