Predicted Trait | |
Reported Trait | Colorectal cancer |
Mapped Trait(s) | colorectal cancer (MONDO_0005575) |
Additional Trait Information | PheCode 153 |
Score Construction | |
PGS Name | PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_UKB_20200608 |
Development Method | |
Name | GWAS Hits |
Parameters | LD Clumping (MAF >= 1%, r^2 <= 0.1) & P<=5e-08 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 74 |
Effect Weight Type | NR |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000118 |
Citation (link to publication) | Fritsche LG et al. Am J Hum Genet (2020) |
Study Identifiers
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Sample Numbers
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Sample Ancestry
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Cohort(s)
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Europe PMC: 30510241 | [
| European | NR |
Study Identifiers
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Sample Numbers
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Sample Ancestry
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Cohort(s)
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Phenotype Definitions & Methods
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Age of Study Participants
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Participant Follow-up Time
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Additional Ancestry Description
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Additional Sample/Cohort Information
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Europe PMC: 32991828 | [
| European | UKB | PheCode:153; ICD9:154.8; ICD10:C18.0, C18.1, C18.2, C18.3, C18.4, C18.5, C18.6, C18.7, C18.8, C18.9,... C19, C20, C21.0, C21.1, C21.8, C26.0, D01.0, D01.1, D01.2, D01.3Show more | — | — | — | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
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PPM001053 | PSS000564| European Ancestry| 24,996 individuals | PGP000118 | Fritsche LG et al. Am J Hum Genet (2020) | Reported Trait: Colorectal cancer | OR: 1.516 [1.451, 1.585] β: 0.416 (0.0225) | AUROC: 0.612 [0.6, 0.625] | Nagelkerke's Pseudo-R²: 0.0304 Brier score: 0.0813 Odds Ratio (OR, top 1% vs. Rest): 3.85 [2.99, 4.96] | age, sex, batch PCs 1-4 | Cancer PRSweb PheWAS Results: PRSWEB_PHECODE153_CRC-Huyghe_P_5e-08_UKB_20200608 |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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PSS000564 | PheCode:153; ICD9:154.8; ICD10:C18.0, C18.1, C18.2, C18.3, C18.4, C18.5, C18.6, C18.7, C18.8, C18.9,... C19, C20, C21.0, C21.1, C21.8, C26.0, D01.0, D01.1, D01.2, D01.3Show more | — | [
| — | European | — | UKB | — |