| Predicted Trait | |
| Reported Trait | Body surface area-indexed left ventricular end-systolic volume |
| Mapped Trait(s) | left ventricular systolic function measurement (EFO_0008206) |
| Score Construction | |
| PGS Name | PGS_LVESVi |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | p<5e-8 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 28 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000126 |
| Citation (link to publication) | Pirruccello JP et al. Nat Commun (2020) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 98.2% South Asian: 0.8% Not Reported: 0.4% African: 0.3% East Asian: 0.3% 36,041 individuals (100%) |
| PGS Evaluation | |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST010127 Europe PMC: 32382064 |
95 individuals | African unspecified | UKB |
GWAS Catalog: GCST010127 Europe PMC: 32382064 |
128 individuals | NR | UKB |
GWAS Catalog: GCST010127 Europe PMC: 32382064 |
35,407 individuals | European | UKB |
GWAS Catalog: GCST010127 Europe PMC: 32382064 |
108 individuals | East Asian | UKB |
GWAS Catalog: GCST010127 Europe PMC: 32382064 |
303 individuals | South Asian | UKB |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM001376 | PSS000603| Ancestry Not Reported| 449,027 individuals |
PGP000126 | Pirruccello JP et al. Nat Commun (2020) |
Reported Trait: Nonischemic dilated cardiomyopathy | OR: 1.51 | — | — | age at enrollment, genotyping array, PCs(1-5) of ancestry. | — |
| PPM001377 | PSS000604| Multi-ancestry (including European)| 362,922 individuals |
PGP000126 | Pirruccello JP et al. Nat Commun (2020) |
Reported Trait: Incident nonischemic dilated cardiomyopathy | HR: 1.58 [1.43, 1.76] | — | — | cubic basis spline of age at enrollment, sex, genotyping array, PCs(1-5) of ancestry. | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000603 | Hospitalization for or death due to ICD-10 code for dilated cardiomyopathy (I42.0); excluding individuals with history of coronary artery disease (as defined below), or history of hypertrophic cardiomyopathy during verbal interview with trained nurse, or hospitalization for or death due to ICD-10 code for hypertrophic cardiomyopathy (I42.1, I42.2) | — | [
|
— | NR | — | UKB | — |
| PSS000604 | Incident DCM: Hospitalization for or death due to ICD-10 code for dilated cardiomyopathy (I42.0); excluding individuals with history of coronary artery disease (as defined below), or history of hypertrophic cardiomyopathy during verbal interview with trained nurse, or hospitalization for or death due to ICD-10 code for hypertrophic cardiomyopathy (I42.1, I42.2).In participants who had not undergone cardiac MRI, were free from CHF, DCM, and CAD at baseline, and who were not identified by the UK Biobank as having third-degree or closer relatedness to another participant. | — | [ ,
45.0 % Male samples |
Mean = 57.0 years Sd = 8.1 years |
European, South Asian, African unspecified, East Asian, NR | African unspecified = 2937, East Asain = 1303, European = 348778, NR = 3670, South Asian =6234 | UKB | — |