| Predicted Trait | |
| Reported Trait | Kidney failure |
| Mapped Trait(s) | kidney failure (EFO_1002048) |
| Additional Trait Information | Unadjusted weights |
| Score Construction | |
| PGS Name | HC294 |
| Development Method | |
| Name | snpnet (multi-PRS) |
| Parameters | Weighted combination of multiple biomarker PRS. 1,080,968 variants as input (directly genotyped variants, imputed HLA allelotypes, and CNVs) |
| Variants | |
| Original Genome Build | hg19 |
| Number of Variants | 183,272 |
| Effect Weight Type | weights.HC294 |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000128 |
| Citation (link to publication) | Sinnott-Armstrong N et al. Nat Genet (2021) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 223,327 individuals (100%) |
| PGS Evaluation | European: 100% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
Europe PMC: 10.1038/s41588-020-00757-z |
223,327 individuals | European (British) |
UKB | — | — | — | — | Training |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM001608 | PSS000829| European Ancestry| 135,300 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Renal failure | HR: 1.12 [1.08, 1.16] | C-index: 0.667 | — | Age as time scale, sex, batch, PCs(1-10) | — |
| PPM001600 | PSS000823| European Ancestry| 87,413 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Kidney failure | — | AUROC: 0.56142 | — | Age, sex, PCs(1-10) | — |
| PPM001609 | PSS000804| European Ancestry| 135,300 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Dialysis | HR: 1.13 [1.04, 1.23] | C-index: 0.745 | — | Age as time scale, sex, batch, PCs(1-10) | — |
| PPM001610 | PSS000682| European Ancestry| 135,300 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Diabetic kidney failure in all | HR: 1.19 [1.13, 1.26] | C-index: 0.779 | — | Age as time scale, sex, batch, PCs(1-10) | — |
| PPM001611 | PSS000682| European Ancestry| 135,300 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Diabetic kidney failure in diabetics | HR: 1.08 [1.02, 1.14] | C-index: 0.706 | — | Age as time scale, sex, batch, PCs(1-10) | — |
| PPM001612 | PSS000683| European Ancestry| 135,300 individuals |
PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) |
Reported Trait: Diabetic kidney failure in type 2 diabetics | HR: 1.13 [1.04, 1.24] | C-index: 0.634 | — | Age as time scale, sex, batch, PCs(1-10) | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000682 | ICD-10 E1[0-4]2 | — | [
|
— | European (Finnish) |
— | FinnGen | — |
| PSS000683 | ICD-10 E1[0-4]2 | — | [
|
— | European (Finnish) |
— | FinnGen | — |
| PSS000823 | — | — | 87,413 individuals | — | European | — | UKB | — |
| PSS000829 | ICD-10 N17 | — | [
|
— | European (Finnish) |
— | FinnGen | — |
| PSS000804 | ICD-10 Z992|Y841 | — | [
|
— | European (Finnish) |
— | FinnGen | — |