| Predicted Trait | |
| Reported Trait | T2D (cases vs HbA1c filtered controls) |
| Mapped Trait(s) | type 2 diabetes mellitus (MONDO_0005148) |
| Additional Trait Information | Unadjusted weights |
| Score Construction | |
| PGS Name | T2D_HbA1c_39 |
| Development Method | |
| Name | snpnet (multi-PRS) |
| Parameters | Weighted combination of multiple biomarker PRS. 1,080,968 variants as input (directly genotyped vari... ants, imputed HLA allelotypes, and CNVs)Show more |
| Variants | |
| Original Genome Build | hg19 |
| Number of Variants | 183,695 |
| Effect Weight Type | weights.T2D_HbA1c_39 |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000128 |
| Citation (link to publication) | Sinnott-Armstrong N et al. Nat Genet (2021) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 223,327 individuals (100%) |
| PGS Evaluation | European: 100% 1 Sample Sets |
Study Identifiers
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Sample Numbers
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Sample Ancestry
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Cohort(s)
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Phenotype Definitions & Methods
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Age of Study Participants
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Participant Follow-up Time
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Additional Ancestry Description
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Additional Sample/Cohort Information
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|---|---|---|---|---|---|---|---|---|
Europe PMC: 10.1038/s41588-020-00757-z | 223,327 individuals | European (British) | UKB | — | — | — | — | Training |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
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Trait
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PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
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PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM001604 | PSS000755| European Ancestry| 87,413 individuals | PGP000128 | Sinnott-Armstrong N et al. Nat Genet (2021) | Reported Trait: Type 2 diabetes | — | AUROC: 0.68713 | — | Age, sex, PCs(1-10) | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
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Sample Ancestry
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Additional Ancestry Description
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Cohort(s)
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Additional Sample/Cohort Information
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|---|---|---|---|---|---|---|---|---|
| PSS000755 | — | — | 87,413 individuals | — | European | — | UKB | — |