| Predicted Trait | |
| Reported Trait | Prostate cancer |
| Mapped Trait(s) | prostate carcinoma (EFO_0001663) |
| Score Construction | |
| PGS Name | PRS_Prostate |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | NR |
| Variants | |
| Original Genome Build | hg19 |
| Number of Variants | 134 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000135 |
| Citation (link to publication) | Jia G et al. JNCI Cancer Spectr (2020) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 140,254 individuals (100%) |
| PGS Evaluation | European: 100% 1 Sample Sets |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
GWAS Catalog: GCST006085 Europe PMC: 29892016 | 140,254 individuals | European | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
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Other Metrics
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Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM001644 | PSS000860| European Ancestry| 400,812 individuals | PGP000135 | Jia G et al. JNCI Cancer Spectr (2020) | Reported Trait: Incident prostate cancer | — | AUROC: 0.662 [0.655, 0.67] | — | Genotyping array | — |
| PPM001645 | PSS000860| European Ancestry| 400,812 individuals | PGP000135 | Jia G et al. JNCI Cancer Spectr (2020) | Reported Trait: Incident prostate cancer | — | AUROC: 0.669 [0.661, 0.676] | — | family history of cancer (in first-degree relatives), genotyping array | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
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Participant Follow-up Time
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Sample Numbers
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Age of Study Participants
|
Sample Ancestry
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Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS000860 | Data and diagnoses on site-specific incident cancers were provided by the National Health Service In... formation Centre for participants from England and Wales (follow-up through March 31, 2016) and by the NHS Central Register Scotland for participants from Scotland (follow-up through October 31, 2015). Cancers were coded by the International Classification of Diseases, Ninth Revision (ICD-9) or the International Classification of Diseases, Tenth Revision (ICD-10). Prostate=(ICD-9 = 185 or ICD-10 = C61)Show more | Median = 5.8 years | [ ,
46.5 % Male samples | — | European | — | UKB | — |