Polygenic Score (PGS) ID: PGS000770

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: May 28, 2021
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS231
Development Method
Name Genome-wide significant SNPs, SNPs with suggestive evidence of association
Parameters Genome-wide = p<5e-8, suggestive = p<1e-6
Variants
Original Genome Build NCBI36
Number of Variants 231
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000177
Citation (link to publication) de Toro-Martín J et al. Front Genet (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 76.8%
East Asian: 15.2%
African: 5.7%
Additional Asian Ancestries: 1%
South Asian: 0.6%
Hispanic or Latin American: 0.5%
Multi-ancestry (excluding European): 0.3%
  • South Asian
  • Additional Asian Ancestries
  • East Asian
884,136 individuals (100%)
Score Development/Training
European: 100%
704 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
JSONXMLCSVTXTMS-Excel
Loading, please wait
Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST000090
Europe PMC: 17903300
1,341 individualsEuropeanFHS
GWAS Catalog: GCST000185
Europe PMC: 18454148
16,876 individualsEuropean6 cohorts
  • B58C
  • ,CoLaus
  • ,EPIC-Obesity
  • ,UKBS
  • ,WTCCC
  • ,WTCCC_CAD
GWAS Catalog: GCST000296
Europe PMC: 19079260
72,598 individualsEuropeanJH-SFHS, NBCS, NBS, RUNMC, deCODE
GWAS Catalog: GCST000296
Europe PMC: 19079260
1,160 individualsAfrican American or Afro-CaribbeanJH-SFHS, NBCS, NBS, RUNMC, deCODE
GWAS Catalog: GCST000298
Europe PMC: 19079261
32,387 individualsEuropean
(Italy)		12 cohorts
  • B58C
  • ,CoLaus
  • ,DGI
  • ,EPIC-Obesity
  • ,FUSION
  • ,KORA
  • ,NHS
  • ,PLCO
  • ,SardiNIA
  • ,UKBS
  • ,WTCCC
  • ,WTCCC_CAD
GWAS Catalog: GCST000512
Europe PMC: 19851299
3,925 individualsEuropeanCROATIA-VIS, ERF, MICROS, NSPHS, ORCADES
GWAS Catalog: GCST000642
Europe PMC: 20397748
11,536 individualsEuropeanATR
GWAS Catalog: GCST000830
Europe PMC: 20935630
123,865 individualsEuropean44 cohorts
  • ADVANCE
  • ,AGES
  • ,ARIC
  • ,B58C
  • ,BRIGHT
  • ,CAPS
  • ,CHS
  • ,CROATIA-VIS
  • ,CoLaus
  • ,DGI
  • ,EGCUT
  • ,EPIC-Obesity
  • ,ERF
  • ,FHS
  • ,FTC
  • ,FUSION
  • ,FamHS
  • ,Fenland
  • ,GENMETS
  • ,GerMIFS
  • ,HAPI
  • ,KORA
  • ,MICROS
  • ,MIGen
  • ,NESDA
  • ,NFBC
  • ,NHS
  • ,NSPHS
  • ,NTR
  • ,ORCADES
  • ,PLCO
  • ,PROCARDIS
  • ,RS
  • ,RUNMC
  • ,SASBAC
  • ,SEARCH
  • ,SHIP
  • ,SardiNIA
  • ,TwinsUK
  • ,UKBS
  • ,UKOPS
  • ,WTCCC
  • ,WTCCC_CAD
  • ,deCODE
GWAS Catalog: GCST000840
Europe PMC: 20966902
1,780 individualsSouth East AsianCLHNS
GWAS Catalog: GCST001125
Europe PMC: 21701570
1,715 individualsAfrican American or Afro-CaribbeanWFSM
GWAS Catalog: GCST001415
Europe PMC: 22344219
22,762 individualsEast Asian8 cohorts
  • CAGE
  • ,CRC
  • ,KARE
  • ,SDCS
  • ,SGWAS
  • ,SIMES
  • ,SP2
  • ,TGWAS
GWAS Catalog: GCST001415
Europe PMC: 22344219
2,522 individualsSouth East Asian8 cohorts
  • CAGE
  • ,CRC
  • ,KARE
  • ,SDCS
  • ,SGWAS
  • ,SIMES
  • ,SP2
  • ,TGWAS
GWAS Catalog: GCST001415
Europe PMC: 22344219
2,431 individualsSouth Asian, South East Asian, East Asian8 cohorts
  • CAGE
  • ,CRC
  • ,KARE
  • ,SDCS
  • ,SGWAS
  • ,SIMES
  • ,SP2
  • ,TGWAS
GWAS Catalog: GCST001416
Europe PMC: 22344221
26,620 individualsEast AsianBBJ
GWAS Catalog: GCST001448
Europe PMC: 22446040
5,218 individualsEuropeanFUSION, Marshfield, SAGE
Showing 1 to 15 of 32 rows
152550All
rows per page
Score Development/Training
JSONXMLCSVTXTMS-Excel
Loading, please wait
Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
—
[
  • 196 cases
  • , 508 controls
]
,
43.04 % Male samples
European
(French-Canadian)		QFSCases were individuals defined as obese (BMI ≥ 30kg/m2)————
Showing 1 to 1 of 1 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM001987PSS000992|
European Ancestry|
177 individuals
PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
Reported Trait: Obesity——Odds Ratio (OR_Trend): 1.19 [1.06, 1.33]Age, sex, random effect (family relatedness)—
PPM001988PSS000991|
European Ancestry|
141 individuals
PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
Reported Trait: Obesity——Odds Ratio (OR_Trend): 1.12 [1.01, 1.25]Age, sex, random effect (family relatedness)—
PPM001989PSS000992|
European Ancestry|
177 individuals
PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
Reported Trait: Obesity prevalence—AUROC: 0.661—Bootstrapping (n=1000)—
PPM001990PSS000991|
European Ancestry|
141 individuals
PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
Reported Trait: Obesity prevalence—AUROC: 0.619—Bootstrapping (n=1000)—
PPM001991PSS000992|
European Ancestry|
177 individuals
PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
Reported Trait: Obesity prevalence—AUROC: 0.127 [0.04, 0.22]—Age, sex, bootstrapping (n=1000)—
PPM001992PSS000992|
European Ancestry|
177 individuals
PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
Reported Trait: Obesity prevalence——Odds Ratio (OR, top 20% vs bottom 20%): 4.77 [1.54, 16.99]Age, sex, random effect (family relatedness)—
PPM001993PSS000992|
European Ancestry|
177 individuals
PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
Reported Trait: Obesity prevalence——Odds Ratio (OR, middle 40-60% vs bottom 20%): 3.46 [1.11, 12.31]Age, sex, random effect (family relatedness)—
PPM001994PSS000991|
European Ancestry|
141 individuals
PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
Reported Trait: Obesity prevalence——Odds Ratio (OR, middle 60-80% vs bottom 20%): 3.79 [1.07, 15.86]Age, sex, random effect (family relatedness)—
PPM001995PSS000992|
European Ancestry|
177 individuals
PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
Reported Trait: Body mass indexβ: 0.33—R²: 0.032Sex, age—
Showing 1 to 9 of 9 rows

Evaluated Samples

JSONXMLCSVTXTMS-Excel
Loading, please wait
PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS000991Cases were individuals defined as obese (BMI ≥ 30kg/m2)—
[
  • 39 cases
  • , 102 controls
]
,
48.23 % Male samples
—European
(French-Canadian)		—FAS—
PSS000992Cases were individuals defined as obese (BMI ≥ 30kg/m2)—
[
  • 50 cases
  • , 127 controls
]
,
43.5 % Male samples
—European
(French-Canadian)		—QFS—
Showing 1 to 2 of 2 rows