| Predicted Trait | |
| Reported Trait | Insulin sensitivity index |
| Mapped Trait(s) | insulin sensitivity measurement (EFO_0004471) |
| Score Construction | |
| PGS Name | ISI |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | r2=0.5, 250kb window |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 219 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000211 |
| Citation (link to publication) | Aly DM et al. Nat Genet (2021) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 16,753 individuals (100%) |
| PGS Evaluation | European: 83.3% South Asian: 16.7% 6 Sample Sets |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
GWAS Catalog: GCST003659 Europe PMC: 27416945 | 16,753 individuals | European | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM002268 | PSS001086| European Ancestry| 3,194 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Severe Autoimmune Diabetes | OR: 0.92 [0.83, 1.01] | — | — | PC1-10 | — |
| PPM002269 | PSS001087| European Ancestry| 3,930 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Severe Insulin-Deficient Diabetes | OR: 0.93 [0.86, 0.99] | — | — | PC1-10 | — |
| PPM002270 | PSS001088| European Ancestry| 3,869 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Severe Insulin-Resistant Diabetes | OR: 0.84 [0.79, 0.91] | — | — | PC1-10 | — |
| PPM002271 | PSS001085| European Ancestry| 4,116 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Moderate Obesity-related Diabetes | OR: 0.88 [0.82, 0.94] | — | — | PC1-10 | — |
| PPM002272 | PSS001084| European Ancestry| 5,597 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Moderate Age-Related Diabetes | OR: 0.95 [0.9, 1.0] | — | — | PC1-10 | — |
| PPM020179 | PSS011301| South Asian Ancestry| 1,282 individuals | PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. | Reported Trait: HOMA2IR | β: -0.09902 (0.047574) | — | — | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS001084 | Moderate Age-Related Diabetes (MARD) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS001085 | Moderate Obesity-related Diabetes (MOD) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS001086 | Severe Autoimmune Diabetes (SAID) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS001087 | Severe Insulin-Deficient Diabetes (SIDD) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS001088 | Severe Insulin-Resistant Diabetes (SIRD) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS011301 | — | — | [
| — | South Asian (Indian) | — | WellGen | — |