PGS Catalog - PGS000847 / Triglycerides (TG) (Polygenic Score)

Polygenic Score (PGS) ID: PGS000847

Predicted Trait
Reported Trait	Triglycerides (TG)
Mapped Trait(s)	triglyceride measurement (EFO_0004530)

Released in PGS Catalog: Nov. 4, 2021

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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name	TG
Development Method
Name	Genome-wide significant variants
Parameters	r²=0.1, 250kb window
Variants
Original Genome Build	GRCh37
Number of Variants	201
Effect Weight Type	NR

PGS Source
PGS Catalog Publication (PGP) ID	PGP000211
Citation (link to publication)	Aly DM et al. Nat Genet (2021)

Ancestry Distribution
Source of Variant Associations (GWAS)	European: 100% 94,595 individuals (100%)
PGS Evaluation	European: 100% 5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)

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Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
GWAS Catalog: GCST002221 Europe PMC: 24097068	94,595 individuals	European	NR

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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM002318	PSS001086\| European Ancestry\| 3,194 individuals	PGP000211 \| Aly DM et al. Nat Genet (2021)	Reported Trait: Severe Autoimmune Diabetes	OR: 1.02 [0.92, 1.13]	—	—	PC1-10	—
PPM002319	PSS001087\| European Ancestry\| 3,930 individuals	PGP000211 \| Aly DM et al. Nat Genet (2021)	Reported Trait: Severe Insulin-Deficient Diabetes	OR: 0.98 [0.92, 1.05]	—	—	PC1-10	—
PPM002320	PSS001088\| European Ancestry\| 3,869 individuals	PGP000211 \| Aly DM et al. Nat Genet (2021)	Reported Trait: Severe Insulin-Resistant Diabetes	OR: 1.0 [0.94, 1.08]	—	—	PC1-10	—
PPM002321	PSS001085\| European Ancestry\| 4,116 individuals	PGP000211 \| Aly DM et al. Nat Genet (2021)	Reported Trait: Moderate Obesity-related Diabetes	OR: 1.02 [0.96, 1.09]	—	—	PC1-10	—
PPM002322	PSS001084\| European Ancestry\| 5,597 individuals	PGP000211 \| Aly DM et al. Nat Genet (2021)	Reported Trait: Moderate Age-Related Diabetes	OR: 0.99 [0.94, 1.05]	—	—	PC1-10	—

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Evaluated Samples

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PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS001084	Moderate Age-Related Diabetes (MARD) vs. controls	—	5,597 individuals [ 2,853 cases , 2,744 controls ]	—	European	Swedish	ANDIS	—
PSS001085	Moderate Obesity-related Diabetes (MOD) vs. controls	—	4,116 individuals [ 1,372 cases , 2,744 controls ]	—	European	Swedish	ANDIS	—
PSS001086	Severe Autoimmune Diabetes (SAID) vs. controls	—	3,194 individuals [ 450 cases , 2,744 controls ]	—	European	Swedish	ANDIS	—
PSS001087	Severe Insulin-Deficient Diabetes (SIDD) vs. controls	—	3,930 individuals [ 1,186 cases , 2,744 controls ]	—	European	Swedish	ANDIS	—
PSS001088	Severe Insulin-Resistant Diabetes (SIRD) vs. controls	—	3,869 individuals [ 1,125 cases , 2,744 controls ]	—	European	Swedish	ANDIS	—

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