| Predicted Trait | |
| Reported Trait | Type 2 diabetes (based on SNPs associated with lipodystrophy) |
| Mapped Trait(s) | type 2 diabetes mellitus (MONDO_0005148) |
| Score Construction | |
| PGS Name | T2D_Lipodystrophy |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 18 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000211 |
| Citation (link to publication) | Aly DM et al. Nat Genet (2021) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | |
| PGS Evaluation | European: 62.5% South Asian: 37.5% 8 Sample Sets |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
Europe PMC: 30240442 | 17,365 individuals | African American or Afro-Caribbean, East Asian, European, Hispanic or Latin American, South Asian, NR | METSIM, PHB, UKB |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM002358 | PSS001086| European Ancestry| 3,194 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Severe Autoimmune Diabetes | OR: 1.12 [1.01, 1.25] | — | — | PC1-10 | — |
| PPM002359 | PSS001087| European Ancestry| 3,930 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.23 [1.15, 1.33] | — | — | PC1-10 | — |
| PPM002360 | PSS001088| European Ancestry| 3,869 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.15 [1.07, 1.24] | — | — | PC1-10 | — |
| PPM002361 | PSS001085| European Ancestry| 4,116 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Moderate Obesity-related Diabetes | OR: 1.14 [1.06, 1.22] | — | — | PC1-10 | — |
| PPM002362 | PSS001084| European Ancestry| 5,597 individuals | PGP000211 | Aly DM et al. Nat Genet (2021) | Reported Trait: Moderate Age-Related Diabetes | OR: 1.18 [1.11, 1.24] | — | — | PC1-10 | — |
| PPM020175 | PSS011301| South Asian Ancestry| 1,282 individuals | PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. | Reported Trait: Type 2 diabetes | OR: 1.17 [1.04, 1.31] | — | — | sex | — |
| PPM020193 | PSS011302| South Asian Ancestry| 830 individuals | PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. | Reported Trait: Severe insulin deficiency diabetes | OR: 1.16 [1.0, 1.34] | — | — | sex | — |
| PPM020203 | PSS011303| South Asian Ancestry| 729 individuals | PGP000525 | Yajnik CS et al. Lancet Reg Health Southeast Asia (2023) |Ext. | Reported Trait: Mild obesity-related diabetes | OR: 1.18 [1.01, 1.37] | — | — | sex | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS001084 | Moderate Age-Related Diabetes (MARD) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS001085 | Moderate Obesity-related Diabetes (MOD) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS001086 | Severe Autoimmune Diabetes (SAID) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS001087 | Severe Insulin-Deficient Diabetes (SIDD) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS001088 | Severe Insulin-Resistant Diabetes (SIRD) vs. controls | — | [
| — | European | Swedish | ANDIS | — |
| PSS011301 | — | — | [
| — | South Asian (Indian) | — | WellGen | — |
| PSS011302 | — | — | [
| — | South Asian (Indian) | — | WellGen | — |
| PSS011303 | — | — | [
| — | South Asian (Indian) | — | WellGen | — |