Polygenic Score (PGS) ID: PGS000867

Predicted Trait
Reported Trait Allergy
Mapped Trait(s) allergic disease (MONDO_0005271)
Released in PGS Catalog: Aug. 26, 2021
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Score Details

Score Construction
PGS Name GRS10_Allergy
Development Method
Name Genome-wide significant variants
Parameters P < 5e-8, r^2 > 0.8 for proxy SNPs
Variants
Original Genome Build hg19
Number of Variants 10
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000213
Citation (link to publication) Arabkhazaeli A et al. Pediatr Allergy Immunol (2017)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
53,862 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST002083
Europe PMC: 23817569
 53,862 individuals European 23andMe, ALSPAC

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002411 PSS001091|
European Ancestry|
1,330 individuals
 PGP000213 |
Arabkhazaeli A et al. Pediatr Allergy Immunol (2017)
 Reported Trait: Time to physician-diagnosed allergy in childhood HR: 1.79 [1.06, 3.02] — — — —
PPM002412 PSS001091|
European Ancestry|
1,330 individuals
 PGP000213 |
Arabkhazaeli A et al. Pediatr Allergy Immunol (2017)
 Reported Trait: Time to physician-diagnosed allergy in childhood HR: 1.89 [1.05, 3.41] — — Age, gender, breastfeeding, family history of asthma, family history of allergies —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001091 Cases were individuals who had been diagnosed by a phsyician with allergic symptoms. Allergic symptoms were diagnoised/defined using the International Classification of Primary Care (ICPC), allergic conjunctivitis (ICPC: F71), allergic rhinitis (ICPC: R97), or eczema/dermatitis (ICPC: S87, S88). Median = 3.6 years
IQR = [1.5, 6.7] years
[
  • 497 cases
  • , 833 controls
]
,
49.2 % Male samples
 Median = 7.0 years
IQR = [4.0, 9.0] years		 European
(Dutch, NR)		 Dutch = 471, NR = 859 WHISTLER —