Polygenic Score (PGS) ID: PGS000880

Predicted Trait
Reported Trait Lung cancer
Mapped Trait(s) lung carcinoma (EFO_0001071)
Released in PGS Catalog: Aug. 26, 2021
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Score Details

Score Construction
PGS Name PRS18_LC
Development Method
Name Genome-wide significant variants
Parameters P < 5e-8
Variants
Original Genome Build GRCh37
Number of Variants 18
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000226
Citation (link to publication) Xie J et al. Sleep (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
85,716 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004748
Europe PMC: 2860473
 85,716 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002521 PSS001139|
European Ancestry|
382,598 individuals
 PGP000226 |
Xie J et al. Sleep (2021)
 Reported Trait: Incident lung cancer HR: 1.2 [1.15, 1.26] — — Sex, education (college or uni- versity degree/vocational qualification, other qualification), smoking status (never, former, current), pack-years, alcohol in- take (nondrinker, <1, 1-10, 10-20, ≥20 g/day), physical activity (Metabolic Equivalent Task hours per week, MET-h/week), and body mass index (BMI, kg/m2) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001139 Cases were individuals with lung cancer. Lung cancer cases were ascertained through record linkage to the National Health Service central registries and death registries. The endpoint was identified using ICD-10 (International Classification of Diseases, 10th revision) codes (C33 and C34). —
[
  • 1,791 cases
  • , 380,807 controls
]
 — European — UKB —