Polygenic Score (PGS) ID: PGS000910

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: Oct. 7, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS_BMI
Development Method
Name SBayesR
Parameters --ldm ldm_ukb_50k_bigset_2.8M\ --pi 0.95,0.02,0.02,0.01 \ --gamma 0.0,0.01,0.1,1 \ --chain-length 25000 \ --burn-in 5000 \ --out-freq 10 \ --exclude-mhc
Variants
Original Genome Build hg19
Number of Variants 735,440
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000238
Citation (link to publication) Campos AI et al. Commun Med (Lond) (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 67%
Not Reported: 33%
681,275 individuals (100%)
PGS Evaluation
European: 100%
10 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006900
Europe PMC: 30124842
 224,849 individuals NR NR
GWAS Catalog: GCST006900
Europe PMC: 30124842
 456,426 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002930 PSS001433|
European Ancestry|
5,719 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Sertraline takers OR: 1.27 [1.19, 1.35] — Variance explained (Nagelkerke's R2*100): 1.57 sex, age at study enrollment, genetic PCs 1-20 —
PPM002931 PSS001429|
European Ancestry|
4,365 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Escitalopram takers OR: 1.22 [1.14, 1.31] — Variance explained (Nagelkerke's R2*100): 1.17 sex, age at study enrollment, genetic PCs 1-20 —
PPM002932 PSS001434|
European Ancestry|
3,967 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Venlafaxine takers OR: 1.23 [1.14, 1.32] — Variance explained (Nagelkerke's R2*100): 1.28 sex, age at study enrollment, genetic PCs 1-20 —
PPM002933 PSS001425|
European Ancestry|
1,657 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Amitriptyline takers OR: 1.27 [1.13, 1.42] — Variance explained (Nagelkerke's R2*100): 1.74 sex, age at study enrollment, genetic PCs 1-20 —
PPM002935 PSS001427|
European Ancestry|
2,524 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Desvenlafaxine takers OR: 1.24 [1.13, 1.36] — Variance explained (Nagelkerke's R2*100): 1.36 sex, age at study enrollment, genetic PCs 1-20 —
PPM002936 PSS001426|
European Ancestry|
2,585 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Citalopram takers OR: 1.39 [1.26, 1.53] — Variance explained (Nagelkerke's R2*100): 2.83 sex, age at study enrollment, genetic PCs 1-20 —
PPM002937 PSS001430|
European Ancestry|
3,670 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Fluoxetine takers OR: 1.3 [1.2, 1.4] — Variance explained (Nagelkerke's R2*100): 1.87 sex, age at study enrollment, genetic PCs 1-20 —
PPM002938 PSS001428|
European Ancestry|
1,995 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Duloxetine takers OR: 1.21 [1.1, 1.34] — Variance explained (Nagelkerke's R2*100): 1.26 sex, age at study enrollment, genetic PCs 1-20 —
PPM002934 PSS001431|
European Ancestry|
1,987 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Mirtazapine takers OR: 1.21 [1.1, 1.33] — Variance explained (Nagelkerke's R2*100): 1.23 sex, age at study enrollment, genetic PCs 1-20 —
PPM002939 PSS001432|
European Ancestry|
1,580 individuals
 PGP000238 |
Campos AI et al. Commun Med (Lond) (2021)
 Reported Trait: Weight gain in Paroxetine takers OR: 1.19 [1.06, 1.33] — Variance explained (Nagelkerke's R2*100): 0.84 sex, age at study enrollment, genetic PCs 1-20 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001425 — —
[
  • 140 cases
  • , 1,517 controls
]
 — European — AGDS —
PSS001426 — —
[
  • 367 cases
  • , 2,218 controls
]
 — European — AGDS —
PSS001427 — —
[
  • 489 cases
  • , 2,035 controls
]
 — European — AGDS —
PSS001428 — —
[
  • 382 cases
  • , 1,613 controls
]
 — European — AGDS —
PSS001429 — —
[
  • 712 cases
  • , 3,653 controls
]
 — European — AGDS —
PSS001430 — —
[
  • 583 cases
  • , 3,087 controls
]
 — European — AGDS —
PSS001431 — —
[
  • 186 cases
  • , 1,801 controls
]
 — European — AGDS —
PSS001432 — —
[
  • 236 cases
  • , 1,344 controls
]
 — European — AGDS —
PSS001433 — —
[
  • 1,020 cases
  • , 4,699 controls
]
 — European — AGDS —
PSS001434 — —
[
  • 794 cases
  • , 3,173 controls
]
 — European — AGDS —