Polygenic Score (PGS) ID: PGS001049

Predicted Trait
Reported Trait Risk taking behaviour
Mapped Trait(s) risk-taking behaviour (EFO_0008579)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN2040
Released in PGS Catalog: Oct. 21, 2021
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Score Details

Score Construction
PGS Name GBE_BIN2040
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 4,299
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
261,424 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 68,497 cases
  • , 192,927 controls
]
 European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008003 PSS003662|
African Ancestry|
5,964 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Risk taking — AUROC: 0.59355 [0.57906, 0.60804] R²: 0.03496
Incremental AUROC (full-covars): -0.0057
PGS R2 (no covariates): 0.00026
PGS AUROC (no covariates): 0.50522 [0.4904, 0.52004]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008004 PSS003663|
East Asian Ancestry|
1,452 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Risk taking — AUROC: 0.59928 [0.56724, 0.63133] R²: 0.03735
Incremental AUROC (full-covars): -0.00238
PGS R2 (no covariates): 0.00298
PGS AUROC (no covariates): 0.52192 [0.48914, 0.5547]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008005 PSS003664|
European Ancestry|
23,683 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Risk taking — AUROC: 0.60288 [0.59552, 0.61025] R²: 0.04022
Incremental AUROC (full-covars): 0.00695
PGS R2 (no covariates): 0.00623
PGS AUROC (no covariates): 0.53993 [0.53236, 0.54751]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008006 PSS003665|
South Asian Ancestry|
6,771 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Risk taking — AUROC: 0.56132 [0.54743, 0.57521] R²: 0.01506
Incremental AUROC (full-covars): -0.00071
PGS R2 (no covariates): 0.00151
PGS AUROC (no covariates): 0.5197 [0.50576, 0.53364]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM008007 PSS003666|
European Ancestry|
65,315 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Risk taking — AUROC: 0.63039 [0.6256, 0.63519] R²: 0.05769
Incremental AUROC (full-covars): 0.00651
PGS R2 (no covariates): 0.00565
PGS AUROC (no covariates): 0.53937 [0.53435, 0.54439]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003662 — —
[
  • 2,566 cases
  • , 3,398 controls
]
 — African unspecified — UKB —
PSS003663 — —
[
  • 429 cases
  • , 1,023 controls
]
 — East Asian — UKB —
PSS003664 — —
[
  • 8,855 cases
  • , 14,828 controls
]
 — European non-white British ancestry UKB —
PSS003665 — —
[
  • 2,703 cases
  • , 4,068 controls
]
 — South Asian — UKB —
PSS003666 — —
[
  • 17,186 cases
  • , 48,129 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)