Polygenic Score (PGS) ID: PGS001049

Predicted Trait
Reported Trait Risk taking behaviour
Mapped Trait(s) risk-taking behaviour (EFO_0008579)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN2040
Released in PGS Catalog: Oct. 21, 2021
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_BIN2040
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 4,299
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
261,424 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
—
[
  • 68,497 cases
  • , 192,927 controls
]
EuropeanUKB———white British ancestry—
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM008003PSS003662|
African Ancestry|
5,964 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Risk taking—AUROC: 0.59355 [0.57906, 0.60804]R²: 0.03496
Incremental AUROC (full-covars): -0.0057
PGS R2 (no covariates): 0.00026
PGS AUROC (no covariates): 0.50522 [0.4904, 0.52004]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
PPM008004PSS003663|
East Asian Ancestry|
1,452 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Risk taking—AUROC: 0.59928 [0.56724, 0.63133]R²: 0.03735
Incremental AUROC (full-covars): -0.00238
PGS R2 (no covariates): 0.00298
PGS AUROC (no covariates): 0.52192 [0.48914, 0.5547]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
PPM008005PSS003664|
European Ancestry|
23,683 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Risk taking—AUROC: 0.60288 [0.59552, 0.61025]R²: 0.04022
Incremental AUROC (full-covars): 0.00695
PGS R2 (no covariates): 0.00623
PGS AUROC (no covariates): 0.53993 [0.53236, 0.54751]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
PPM008006PSS003665|
South Asian Ancestry|
6,771 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Risk taking—AUROC: 0.56132 [0.54743, 0.57521]R²: 0.01506
Incremental AUROC (full-covars): -0.00071
PGS R2 (no covariates): 0.00151
PGS AUROC (no covariates): 0.5197 [0.50576, 0.53364]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
PPM008007PSS003666|
European Ancestry|
65,315 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Risk taking—AUROC: 0.63039 [0.6256, 0.63519]R²: 0.05769
Incremental AUROC (full-covars): 0.00651
PGS R2 (no covariates): 0.00565
PGS AUROC (no covariates): 0.53937 [0.53435, 0.54439]		age, sex, UKB array type, Genotype PCsFull Model & PGS R2 is estimated using Nagelkerke's method
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS003662——
[
  • 2,566 cases
  • , 3,398 controls
]
—African unspecified—UKB—
PSS003663——
[
  • 429 cases
  • , 1,023 controls
]
—East Asian—UKB—
PSS003664——
[
  • 8,855 cases
  • , 14,828 controls
]
—Europeannon-white British ancestryUKB—
PSS003665——
[
  • 2,703 cases
  • , 4,068 controls
]
—South Asian—UKB—
PSS003666——
[
  • 17,186 cases
  • , 48,129 controls
]
—Europeanwhite British ancestryUKBTesting cohort (heldout set)
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