Polygenic Score (PGS) ID: PGS001070

Predicted Trait
Reported Trait Volume of ventricular cerebrospinal fluid (normalised for head size)
Mapped Trait(s) cerebrospinal fluid volume measurement (EFO_0008080)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25003
Released in PGS Catalog: Oct. 21, 2021
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Score Details

Score Construction
PGS Name GBE_INI25003
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 880
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
22,323 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 22,323 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008108 PSS005196|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.29254 [0.27395, 0.31114]
Incremental R2 (full-covars): 0.01574
PGS R2 (no covariates): 0.00903 [0.00446, 0.01361]		 age, sex, UKB array type, Genotype PCs —
PPM008109 PSS005197|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.3397 [0.30323, 0.37618]
Incremental R2 (full-covars): 0.00796
PGS R2 (no covariates): 0.01224 [0.00189, 0.0226]		 age, sex, UKB array type, Genotype PCs —
PPM008110 PSS005198|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.2568 [0.24745, 0.26615]
Incremental R2 (full-covars): 0.01559
PGS R2 (no covariates): 0.0141 [0.01119, 0.01701]		 age, sex, UKB array type, Genotype PCs —
PPM008111 PSS005199|
South Asian Ancestry|
329 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.39225 [0.3754, 0.4091]
Incremental R2 (full-covars): 0.00541
PGS R2 (no covariates): 0.00534 [0.00212, 0.00856]		 age, sex, UKB array type, Genotype PCs —
PPM008112 PSS005200|
European Ancestry|
5,445 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of ventricular cerebrospinal fluid (normalised for head size) — — R²: 0.25764 [0.25195, 0.26333]
Incremental R2 (full-covars): 0.01868
PGS R2 (no covariates): 0.01638 [0.01448, 0.01828]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS005196 — — 200 individuals — African unspecified — UKB —
PSS005197 — — 113 individuals — East Asian — UKB —
PSS005198 — — 1,739 individuals — European non-white British ancestry UKB —
PSS005199 — — 329 individuals — South Asian — UKB —
PSS005200 — — 5,445 individuals — European white British ancestry UKB Testing cohort (heldout set)