Predicted Trait | |
Reported Trait | Right leg mass (predicted) |
Mapped Trait(s) | body composition measurement (EFO_0005106) |
Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI23114 |
Score Construction | |
PGS Name | GBE_INI23114 |
Development Method | |
Name | snpnet |
Parameters | NR |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 32,103 |
Effect Weight Type | NR |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000244 |
Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
Ancestry Distribution | |
Score Development/Training | European: 100% 265,156 individuals (100%) |
PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 265,156 individuals | European | UKB | — | — | — | white British ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM008517 | PSS005101| African Ancestry| 6,305 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Leg pred. mass (R) | — | — | R²: 0.55037 [0.53416, 0.56658] Incremental R2 (full-covars): 0.00902 PGS R2 (no covariates): 0.01506 [0.00918, 0.02093] |
age, sex, UKB array type, Genotype PCs | — |
PPM008518 | PSS005102| East Asian Ancestry| 1,680 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Leg pred. mass (R) | — | — | R²: 0.73877 [0.71749, 0.76005] Incremental R2 (full-covars): 0.00137 PGS R2 (no covariates): 0.01373 [0.00278, 0.02468] |
age, sex, UKB array type, Genotype PCs | — |
PPM008519 | PSS005103| European Ancestry| 24,461 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Leg pred. mass (R) | — | — | R²: 0.71438 [0.70839, 0.72038] Incremental R2 (full-covars): 0.04346 PGS R2 (no covariates): 0.04404 [0.03906, 0.04902] |
age, sex, UKB array type, Genotype PCs | — |
PPM008520 | PSS005104| South Asian Ancestry| 7,649 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Leg pred. mass (R) | — | — | Incremental R2 (full-covars): 0.03277 R²: 0.66736 [0.65533, 0.67939] PGS R2 (no covariates): 0.02632 [0.01932, 0.03331] |
age, sex, UKB array type, Genotype PCs | — |
PPM008521 | PSS005105| European Ancestry| 66,257 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Leg pred. mass (R) | — | — | R²: 0.70913 [0.70543, 0.71283] Incremental R2 (full-covars): 0.04958 PGS R2 (no covariates): 0.04812 [0.04497, 0.05127] |
age, sex, UKB array type, Genotype PCs | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS005101 | — | — | 6,305 individuals | — | African unspecified | — | UKB | — |
PSS005102 | — | — | 1,680 individuals | — | East Asian | — | UKB | — |
PSS005103 | — | — | 24,461 individuals | — | European | non-white British ancestry | UKB | — |
PSS005104 | — | — | 7,649 individuals | — | South Asian | — | UKB | — |
PSS005105 | — | — | 66,257 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |