Polygenic Score (PGS) ID: PGS001185

Predicted Trait
Reported Trait Intra-ocular pressure, Goldmann-correlated (R)
Mapped Trait(s) intraocular pressure measurement (EFO_0004695)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI5255
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI5255
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 3,584
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
65,229 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 65,229 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008604 PSS007441|
African Ancestry|
3,254 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Intra-ocular pressure, Goldmann-correlated (R) — — R²: 0.04204 [0.0325, 0.05159]
Incremental R2 (full-covars): 0.0098
PGS R2 (no covariates): 0.01237 [0.00703, 0.01771]		 age, sex, UKB array type, Genotype PCs —
PPM008605 PSS007442|
East Asian Ancestry|
590 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Intra-ocular pressure, Goldmann-correlated (R) — — R²: 0.02998 [0.01406, 0.04589]
Incremental R2 (full-covars): 0.00098
PGS R2 (no covariates): 0.00467 [-0.00178, 0.01112]		 age, sex, UKB array type, Genotype PCs —
PPM008606 PSS007443|
European Ancestry|
7,821 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Intra-ocular pressure, Goldmann-correlated (R) — — R²: 0.04477 [0.03975, 0.04979]
Incremental R2 (full-covars): 0.03528
PGS R2 (no covariates): 0.0349 [0.03042, 0.03937]		 age, sex, UKB array type, Genotype PCs —
PPM008607 PSS007444|
South Asian Ancestry|
3,610 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Intra-ocular pressure, Goldmann-correlated (R) — — R²: 0.03832 [0.02998, 0.04666]
Incremental R2 (full-covars): 0.02757
PGS R2 (no covariates): 0.02719 [0.02009, 0.03429]		 age, sex, UKB array type, Genotype PCs —
PPM008608 PSS007445|
European Ancestry|
16,290 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Intra-ocular pressure, Goldmann-correlated (R) — — R²: 0.05173 [0.04848, 0.05499]
Incremental R2 (full-covars): 0.04479
PGS R2 (no covariates): 0.04483 [0.04178, 0.04788]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007441 — — 3,254 individuals — African unspecified — UKB —
PSS007442 — — 590 individuals — East Asian — UKB —
PSS007443 — — 7,821 individuals — European non-white British ancestry UKB —
PSS007444 — — 3,610 individuals — South Asian — UKB —
PSS007445 — — 16,290 individuals — European white British ancestry UKB Testing cohort (heldout set)