Predicted Trait | |
Reported Trait | Ease of skin tanning (get mildly or occasionally tanned) |
Mapped Trait(s) | suntan (EFO_0004279) |
Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN_FC30001727 |
Score Construction | |
PGS Name | GBE_BIN_FC30001727 |
Development Method | |
Name | snpnet |
Parameters | NR |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 958 |
Effect Weight Type | NR |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000244 |
Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
Ancestry Distribution | |
Score Development/Training | European: 100% 264,822 individuals (100%) |
PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | [
|
European | UKB | — | — | — | white British ancestry | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM008729 | PSS003879| African Ancestry| 4,524 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Ease of skin tanning (Get mildly or occasionally tanned) | — | AUROC: 0.52345 [0.50398, 0.54292] | R²: 0.00289 Incremental AUROC (full-covars): -0.04291 PGS R2 (no covariates): 0.00485 PGS AUROC (no covariates): 0.46513 [0.44563, 0.48463] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PPM008730 | PSS003880| East Asian Ancestry| 1,541 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Ease of skin tanning (Get mildly or occasionally tanned) | — | AUROC: 0.54571 [0.50672, 0.5847] | PGS R2 (no covariates): 0.00029 R²: 0.01015 Incremental AUROC (full-covars): -0.01074 PGS AUROC (no covariates): 0.50235 [0.46279, 0.54191] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PPM008731 | PSS003881| European Ancestry| 24,421 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Ease of skin tanning (Get mildly or occasionally tanned) | — | AUROC: 0.64487 [0.63683, 0.65291] | R²: 0.06277 Incremental AUROC (full-covars): 0.03781 PGS R2 (no covariates): 0.05363 PGS AUROC (no covariates): 0.63901 [0.631, 0.64703] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PPM008732 | PSS003882| South Asian Ancestry| 6,616 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Ease of skin tanning (Get mildly or occasionally tanned) | — | AUROC: 0.5248 [0.50879, 0.54081] | R²: 0.00212 Incremental AUROC (full-covars): -0.01511 PGS R2 (no covariates): 0.00013 PGS AUROC (no covariates): 0.50088 [0.48459, 0.51717] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PPM008733 | PSS003883| European Ancestry| 66,187 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Ease of skin tanning (Get mildly or occasionally tanned) | — | AUROC: 0.63688 [0.63202, 0.64174] | R²: 0.05636 Incremental AUROC (full-covars): 0.0631 PGS R2 (no covariates): 0.04114 PGS AUROC (no covariates): 0.61836 [0.61342, 0.62331] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS003879 | — | — | [
|
— | African unspecified | — | UKB | — |
PSS003880 | — | — | [
|
— | East Asian | — | UKB | — |
PSS003881 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
PSS003882 | — | — | [
|
— | South Asian | — | UKB | — |
PSS003883 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |