Polygenic Score (PGS) ID: PGS001283

Predicted Trait
Reported Trait Allergic disease (hay fever, rhinitis or eczema)
Mapped Trait(s) allergic disease (MONDO_0005271)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI3761
Released in PGS Catalog: Oct. 21, 2021
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI3761
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 993
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
55,834 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 55,834 individuals European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008917 PSS007255|
European Ancestry|
13,999 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age hay fever, rhinitis or eczema diagnosed — — R²: 0.11512 [0.11059, 0.11965]
Incremental R2 (full-covars): 0.01247
PGS R2 (no covariates): 0.0125 [0.01084, 0.01417]		 age, sex, UKB array type, Genotype PCs —
PPM008913 PSS007251|
African Ancestry|
1,401 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age hay fever, rhinitis or eczema diagnosed — — R²: 0.14854 [0.13259, 0.16449]
Incremental R2 (full-covars): -0.0075
PGS R2 (no covariates): 0.00033 [-0.00055, 0.0012]		 age, sex, UKB array type, Genotype PCs —
PPM008914 PSS007252|
East Asian Ancestry|
592 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age hay fever, rhinitis or eczema diagnosed — — R²: 0.08793 [0.0623, 0.11356]
Incremental R2 (full-covars): 0.01315
PGS R2 (no covariates): 0.01568 [0.004, 0.02736]		 age, sex, UKB array type, Genotype PCs —
PPM008915 PSS007253|
European Ancestry|
5,147 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age hay fever, rhinitis or eczema diagnosed — — R²: 0.11614 [0.10866, 0.12362]
Incremental R2 (full-covars): 0.01049
PGS R2 (no covariates): 0.01087 [0.00831, 0.01343]		 age, sex, UKB array type, Genotype PCs —
PPM008916 PSS007254|
South Asian Ancestry|
1,451 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Age hay fever, rhinitis or eczema diagnosed — — R²: 0.11629 [0.10294, 0.12963]
Incremental R2 (full-covars): 0.00477
PGS R2 (no covariates): 0.00527 [0.00207, 0.00846]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007251 — — 1,401 individuals — African unspecified — UKB —
PSS007252 — — 592 individuals — East Asian — UKB —
PSS007253 — — 5,147 individuals — European non-white British ancestry UKB —
PSS007254 — — 1,451 individuals — South Asian — UKB —
PSS007255 — — 13,999 individuals — European white British ancestry UKB Testing cohort (heldout set)