| Predicted Trait | |
| Reported Trait | Mean FA in inferior cerebellar peduncle on FA skeleton (R) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25066 |
| Score Construction | |
| PGS Name | GBE_INI25066 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 946 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 21,081 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 21,081 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM005525 | PSS005361| African Ancestry| 182 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean FA in inferior cerebellar peduncle on FA skeleton (R) | — | — | R²: 0.07125 [0.0592, 0.0833] Incremental R2 (full-covars): -0.01149 PGS R2 (no covariates): 0.00029 [-0.00054, 0.00111] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005526 | PSS005362| East Asian Ancestry| 106 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean FA in inferior cerebellar peduncle on FA skeleton (R) | — | — | R²: 0.09119 [0.06518, 0.11719] Incremental R2 (full-covars): 0.02896 PGS R2 (no covariates): 0.02741 [0.01215, 0.04267] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005527 | PSS005363| European Ancestry| 1,651 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean FA in inferior cerebellar peduncle on FA skeleton (R) | — | — | R²: 0.0878 [0.08108, 0.09451] Incremental R2 (full-covars): -0.0033 PGS R2 (no covariates): 0.00086 [0.00013, 0.00159] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005528 | PSS005364| South Asian Ancestry| 299 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean FA in inferior cerebellar peduncle on FA skeleton (R) | — | — | R²: 0.07166 [0.06066, 0.08266] Incremental R2 (full-covars): 0.00024 PGS R2 (no covariates): 0.00222 [0.00014, 0.00431] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005529 | PSS005365| European Ancestry| 5,120 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean FA in inferior cerebellar peduncle on FA skeleton (R) | — | — | R²: 0.05706 [0.05366, 0.06046] Incremental R2 (full-covars): 0.00454 PGS R2 (no covariates): 0.00504 [0.00398, 0.00611] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS005361 | — | — | 182 individuals | — | African unspecified | — | UKB | — |
| PSS005362 | — | — | 106 individuals | — | East Asian | — | UKB | — |
| PSS005363 | — | — | 1,651 individuals | — | European | non-white British ancestry | UKB | — |
| PSS005364 | — | — | 299 individuals | — | South Asian | — | UKB | — |
| PSS005365 | — | — | 5,120 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |