| Predicted Trait | |
| Reported Trait | Mean ISOVF in cingulum cingulate gyrus on FA skeleton (L) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25475 |
| Score Construction | |
| PGS Name | GBE_INI25475 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 114 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 21,080 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 21,080 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM005950 | PSS005786| African Ancestry| 182 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in cingulum cingulate gyrus on FA skeleton (L) | — | — | R²: 0.06633 [0.05464, 0.07802] Incremental R2 (full-covars): 0.00329 PGS R2 (no covariates): 0.00416 [0.00104, 0.00729] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005951 | PSS005787| East Asian Ancestry| 106 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in cingulum cingulate gyrus on FA skeleton (L) | — | — | R²: 0.06861 [0.04549, 0.09172] Incremental R2 (full-covars): 0.00905 PGS R2 (no covariates): 0.04543 [0.02615, 0.06471] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005952 | PSS005788| European Ancestry| 1,651 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in cingulum cingulate gyrus on FA skeleton (L) | — | — | R²: 0.01544 [0.0124, 0.01848] Incremental R2 (full-covars): 0.00428 PGS R2 (no covariates): 0.00535 [0.00354, 0.00716] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005953 | PSS005789| South Asian Ancestry| 299 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in cingulum cingulate gyrus on FA skeleton (L) | — | — | R²: 0.0504 [0.04096, 0.05984] Incremental R2 (full-covars): 0.00069 PGS R2 (no covariates): 0.00116 [-0.00035, 0.00266] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005954 | PSS005790| European Ancestry| 5,120 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in cingulum cingulate gyrus on FA skeleton (L) | — | — | R²: 0.00578 [0.00464, 0.00692] Incremental R2 (full-covars): 0.00391 PGS R2 (no covariates): 0.0053 [0.00421, 0.00639] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS005788 | — | — | 1,651 individuals | — | European | non-white British ancestry | UKB | — |
| PSS005789 | — | — | 299 individuals | — | South Asian | — | UKB | — |
| PSS005790 | — | — | 5,120 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS005786 | — | — | 182 individuals | — | African unspecified | — | UKB | — |
| PSS005787 | — | — | 106 individuals | — | East Asian | — | UKB | — |