| Predicted Trait | |
| Reported Trait | Mean ISOVF in posterior corona radiata on FA skeleton (L) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25467 |
| Score Construction | |
| PGS Name | GBE_INI25467 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 466 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 21,080 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 21,080 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM005920 | PSS005756| African Ancestry| 182 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in posterior corona radiata on FA skeleton (L) | — | — | R²: 0.1258 [0.11073, 0.14087] Incremental R2 (full-covars): 0.01394 PGS R2 (no covariates): 0.024 [0.01665, 0.03135] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005921 | PSS005757| East Asian Ancestry| 106 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in posterior corona radiata on FA skeleton (L) | — | — | R²: 0.13289 [0.10294, 0.16285] Incremental R2 (full-covars): -0.00535 PGS R2 (no covariates): 0.00064 [-0.00175, 0.00303] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005922 | PSS005758| European Ancestry| 1,651 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in posterior corona radiata on FA skeleton (L) | — | — | R²: 0.06558 [0.05964, 0.07152] Incremental R2 (full-covars): 0.00496 PGS R2 (no covariates): 0.00415 [0.00256, 0.00574] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005923 | PSS005759| South Asian Ancestry| 299 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in posterior corona radiata on FA skeleton (L) | — | — | R²: 0.07722 [0.06586, 0.08857] Incremental R2 (full-covars): -0.00455 PGS R2 (no covariates): 0.00089 [-0.00043, 0.00222] |
age, sex, UKB array type, Genotype PCs | — |
| PPM005924 | PSS005760| European Ancestry| 5,120 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Mean ISOVF in posterior corona radiata on FA skeleton (L) | — | — | R²: 0.06692 [0.06327, 0.07056] Incremental R2 (full-covars): 0.00335 PGS R2 (no covariates): 0.00403 [0.00308, 0.00499] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS005756 | — | — | 182 individuals | — | African unspecified | — | UKB | — |
| PSS005757 | — | — | 106 individuals | — | East Asian | — | UKB | — |
| PSS005758 | — | — | 1,651 individuals | — | European | non-white British ancestry | UKB | — |
| PSS005759 | — | — | 299 individuals | — | South Asian | — | UKB | — |
| PSS005760 | — | — | 5,120 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |