Polygenic Score (PGS) ID: PGS001524

Predicted Trait
Reported Trait Pulse rate (during blood-pressure measurement)
Mapped Trait(s) heart rate (EFO_0004326)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI95
Released in PGS Catalog: Nov. 25, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI95
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 765
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
25,967 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 25,967 individuals European UKB — — — white British ancestry Training + validation cohort (train_val)

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007225 PSS007496|
African Ancestry|
209 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Pulse rate (during blood-pressure measurement) — — R²: 0.06125 [0.04996, 0.07254]
Incremental R2 (full-covars): -0.01473
PGS R2 (no covariates): 0.00497 [0.00156, 0.00838]		 age, sex, UKB array type, Genotype PCs —
PPM007226 PSS007497|
East Asian Ancestry|
141 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Pulse rate (during blood-pressure measurement) — — R²: 0.0637 [0.04131, 0.08609]
Incremental R2 (full-covars): 0.00078
PGS R2 (no covariates): 0.00983 [0.00052, 0.01913]		 age, sex, UKB array type, Genotype PCs —
PPM007227 PSS007498|
European Ancestry|
2,103 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Pulse rate (during blood-pressure measurement) — — R²: 0.02805 [0.02401, 0.0321]
Incremental R2 (full-covars): 0.0191
PGS R2 (no covariates): 0.02008 [0.01663, 0.02353]		 age, sex, UKB array type, Genotype PCs —
PPM007228 PSS007499|
South Asian Ancestry|
381 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Pulse rate (during blood-pressure measurement) — — R²: 0.0378 [0.02951, 0.04608]
Incremental R2 (full-covars): 0.00144
PGS R2 (no covariates): 0.00428 [0.0014, 0.00717]		 age, sex, UKB array type, Genotype PCs —
PPM007229 PSS007500|
European Ancestry|
6,590 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Pulse rate (during blood-pressure measurement) — — R²: 0.01671 [0.0148, 0.01863]
Incremental R2 (full-covars): 0.00704
PGS R2 (no covariates): 0.00724 [0.00596, 0.00851]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007496 — — 209 individuals — African unspecified — UKB —
PSS007497 — — 141 individuals — East Asian — UKB —
PSS007498 — — 2,103 individuals — European non-white British ancestry UKB —
PSS007499 — — 381 individuals — South Asian — UKB —
PSS007500 — — 6,590 individuals — European white British ancestry UKB Testing cohort (heldout set)