PGS Catalog - PGS001527 / QTc interval (QT interval according to Bazett) (Polygenic Score)

Polygenic Score (PGS) ID: PGS001527

Predicted Trait
Reported Trait	QTc interval (QT interval according to Bazett)
Mapped Trait(s)	QT interval (EFO_0004682)
Additional Trait Information	https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI22332

Released in PGS Catalog: Nov. 25, 2021

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Score Details

Score Construction
PGS Name	GBE_INI22332
Development Method
Name	snpnet
Parameters	NR
Variants
Original Genome Build	GRCh37
Number of Variants	115
Effect Weight Type	NR

PGS Source
PGS Catalog Publication (PGP) ID	PGP000244
Citation (link to publication)	Tanigawa Y et al. PLoS Genet (2022)

Ancestry Distribution
Score Development/Training	European: 100% 14,051 individuals (100%)
PGS Evaluation	European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets

Development Samples

Score Development/Training

Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)	Phenotype Definitions & Methods	Age of Study Participants	Participant Follow-up Time	Additional Ancestry Description	Additional Sample/Cohort Information
—	14,051 individuals	European	UKB	—	—	—	white British ancestry	Training + validation cohort (train_val)

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM005310	PSS004976\| African Ancestry\| 120 individuals	PGP000244 \| Tanigawa Y et al. PLoS Genet (2022)	Reported Trait: QTC interval	—	—	R²: 0.19276 [0.17553, 0.20998] Incremental R2 (full-covars): 0.00351 PGS R2 (no covariates): 0.00541 [0.00185, 0.00897]	age, sex, UKB array type, Genotype PCs	—
PPM005311	PSS004977\| East Asian Ancestry\| 68 individuals	PGP000244 \| Tanigawa Y et al. PLoS Genet (2022)	Reported Trait: QTC interval	—	—	R²: 0.21617 [0.18164, 0.25071] Incremental R2 (full-covars): 0.01252 PGS R2 (no covariates): 0.00397 [-0.00198, 0.00991]	age, sex, UKB array type, Genotype PCs	—
PPM005312	PSS004978\| European Ancestry\| 872 individuals	PGP000244 \| Tanigawa Y et al. PLoS Genet (2022)	Reported Trait: QTC interval	—	—	R²: 0.07278 [0.06657, 0.079] Incremental R2 (full-covars): 0.01137 PGS R2 (no covariates): 0.00935 [0.00697, 0.01173]	age, sex, UKB array type, Genotype PCs	—
PPM005313	PSS004979\| South Asian Ancestry\| 201 individuals	PGP000244 \| Tanigawa Y et al. PLoS Genet (2022)	Reported Trait: QTC interval	—	—	R²: 0.07001 [0.05911, 0.0809] Incremental R2 (full-covars): -0.00126 PGS R2 (no covariates): 0.00213 [0.00009, 0.00417]	age, sex, UKB array type, Genotype PCs	—
PPM005314	PSS004980\| European Ancestry\| 3,523 individuals	PGP000244 \| Tanigawa Y et al. PLoS Genet (2022)	Reported Trait: QTC interval	—	—	R²: 0.07628 [0.07243, 0.08013] Incremental R2 (full-covars): 0.01976 PGS R2 (no covariates): 0.02423 [0.02193, 0.02652]	age, sex, UKB array type, Genotype PCs	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS004976	—	—	120 individuals	—	African unspecified	—	UKB	—
PSS004977	—	—	68 individuals	—	East Asian	—	UKB	—
PSS004978	—	—	872 individuals	—	European	non-white British ancestry	UKB	—
PSS004979	—	—	201 individuals	—	South Asian	—	UKB	—
PSS004980	—	—	3,523 individuals	—	European	white British ancestry	UKB	Testing cohort (heldout set)