| Predicted Trait | |
| Reported Trait | Volume of grey matter in Cingulate Gyrus, anterior division (R) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25839 |
| Score Construction | |
| PGS Name | GBE_INI25839 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 244 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006720 | PSS006561| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, anterior division (R) | — | — | R²: 0.14634 [0.13046, 0.16221] Incremental R2 (full-covars): 0.00136 PGS R2 (no covariates): 0.00012 [-0.00041, 0.00066] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006721 | PSS006562| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, anterior division (R) | — | — | R²: 0.19373 [0.1601, 0.22736] Incremental R2 (full-covars): 0.00191 PGS R2 (no covariates): 0.00087 [-0.00192, 0.00367] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006722 | PSS006563| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, anterior division (R) | — | — | R²: 0.0976 [0.0906, 0.10461] Incremental R2 (full-covars): 0.00518 PGS R2 (no covariates): 0.00596 [0.00405, 0.00786] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006723 | PSS006564| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, anterior division (R) | — | — | R²: 0.10966 [0.0966, 0.12271] Incremental R2 (full-covars): 0.00574 PGS R2 (no covariates): 0.00608 [0.00265, 0.00952] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006724 | PSS006565| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, anterior division (R) | — | — | R²: 0.06146 [0.05795, 0.06497] Incremental R2 (full-covars): 0.00632 PGS R2 (no covariates): 0.00672 [0.00549, 0.00795] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006561 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006562 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006563 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006564 | — | — | 329 individuals | — | South Asian | — | UKB | — |
| PSS006565 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |