| Predicted Trait | |
| Reported Trait | Volume of grey matter in Cingulate Gyrus, posterior division (R) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25841 |
| Score Construction | |
| PGS Name | GBE_INI25841 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 652 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006725 | PSS006566| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, posterior division (R) | — | — | R²: 0.26983 [0.25139, 0.28826] Incremental R2 (full-covars): 0.01189 PGS R2 (no covariates): 0.00246 [0.00005, 0.00486] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006726 | PSS006567| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, posterior division (R) | — | — | R²: 0.24169 [0.20636, 0.27702] Incremental R2 (full-covars): 0.02443 PGS R2 (no covariates): 0.0209 [0.00749, 0.03431] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006727 | PSS006568| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, posterior division (R) | — | — | R²: 0.20548 [0.19653, 0.21442] Incremental R2 (full-covars): 0.00106 PGS R2 (no covariates): 0.00487 [0.00315, 0.0066] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006728 | PSS006569| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, posterior division (R) | — | — | R²: 0.24091 [0.22442, 0.25741] Incremental R2 (full-covars): 0.00897 PGS R2 (no covariates): 0.01554 [0.01011, 0.02098] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006729 | PSS006570| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Cingulate Gyrus, posterior division (R) | — | — | R²: 0.18847 [0.18315, 0.19379] Incremental R2 (full-covars): 0.00963 PGS R2 (no covariates): 0.01016 [0.00865, 0.01166] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006566 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006567 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006568 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006569 | — | — | 329 individuals | — | South Asian | — | UKB | — |
| PSS006570 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |