Polygenic Score (PGS) ID: PGS001559

Predicted Trait
Reported Trait Volume of grey matter in Frontal Orbital Cortex (R)
Mapped Trait(s)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25847
Released in PGS Catalog: Nov. 25, 2021
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI25847
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 592
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
22,320 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 22,320 individuals European UKB — — — white British ancestry Training + validation cohort (train_val)

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM006745 PSS006586|
African Ancestry|
200 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Frontal Orbital Cortex (R) — — R²: 0.28826 [0.26969, 0.30683]
Incremental R2 (full-covars): -0.00793
PGS R2 (no covariates): 0.00732 [0.00319, 0.01145]		 age, sex, UKB array type, Genotype PCs —
PPM006746 PSS006587|
East Asian Ancestry|
113 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Frontal Orbital Cortex (R) — — R²: 0.30841 [0.27201, 0.3448]
Incremental R2 (full-covars): 0.02297
PGS R2 (no covariates): 0.06926 [0.04605, 0.09248]		 age, sex, UKB array type, Genotype PCs —
PPM006747 PSS006588|
European Ancestry|
1,739 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Frontal Orbital Cortex (R) — — R²: 0.27058 [0.26116, 0.28]
Incremental R2 (full-covars): 0.01256
PGS R2 (no covariates): 0.01503 [0.01203, 0.01803]		 age, sex, UKB array type, Genotype PCs —
PPM006748 PSS006589|
South Asian Ancestry|
329 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Frontal Orbital Cortex (R) — — R²: 0.25996 [0.24325, 0.27666]
Incremental R2 (full-covars): 0.0003
PGS R2 (no covariates): 4e-05 [-0.00025, 0.00033]		 age, sex, UKB array type, Genotype PCs —
PPM006749 PSS006590|
European Ancestry|
5,443 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Vol. of grey matter in Frontal Orbital Cortex (R) — — R²: 0.22132 [0.21579, 0.22685]
Incremental R2 (full-covars): 0.00973
PGS R2 (no covariates): 0.0094 [0.00795, 0.01085]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS006588 — — 1,739 individuals — European non-white British ancestry UKB —
PSS006589 — — 329 individuals — South Asian — UKB —
PSS006590 — — 5,443 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS006586 — — 200 individuals — African unspecified — UKB —
PSS006587 — — 113 individuals — East Asian — UKB —