| Predicted Trait | |
| Reported Trait | Volume of grey matter in Inferior Frontal Gyrus, pars triangularis (R) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25791 |
| Score Construction | |
| PGS Name | GBE_INI25791 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 697 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006640 | PSS006476| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Frontal Gyrus, pars triangularis (R) | — | — | R²: 0.15747 [0.14122, 0.17372] Incremental R2 (full-covars): -0.00114 PGS R2 (no covariates): 0.00239 [0.00002, 0.00476] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006641 | PSS006477| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Frontal Gyrus, pars triangularis (R) | — | — | R²: 0.07775 [0.05338, 0.10212] Incremental R2 (full-covars): 0.007 PGS R2 (no covariates): 0.00488 [-0.00171, 0.01147] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006642 | PSS006478| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Frontal Gyrus, pars triangularis (R) | — | — | R²: 0.08161 [0.07509, 0.08813] Incremental R2 (full-covars): 0.00419 PGS R2 (no covariates): 0.00435 [0.00272, 0.00599] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006643 | PSS006479| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Frontal Gyrus, pars triangularis (R) | — | — | R²: 0.13462 [0.12056, 0.14867] Incremental R2 (full-covars): 0.01305 PGS R2 (no covariates): 0.01158 [0.00687, 0.01629] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006644 | PSS006480| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Frontal Gyrus, pars triangularis (R) | — | — | R²: 0.06033 [0.05685, 0.06381] Incremental R2 (full-covars): 0.00377 PGS R2 (no covariates): 0.00443 [0.00343, 0.00543] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006476 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006477 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006478 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006479 | — | — | 329 individuals | — | South Asian | — | UKB | — |
| PSS006480 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |