| Predicted Trait | |
| Reported Trait | Volume of grey matter in Inferior Temporal Gyrus, posterior division (L) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25810 |
| Score Construction | |
| PGS Name | GBE_INI25810 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 288 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006680 | PSS006516| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Temporal Gyrus, posterior division (L) | — | — | R²: 0.11284 [0.09836, 0.12733] Incremental R2 (full-covars): 0.0062 PGS R2 (no covariates): 0.00585 [0.00216, 0.00955] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006681 | PSS006517| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Temporal Gyrus, posterior division (L) | — | — | R²: 0.25453 [0.21889, 0.29017] Incremental R2 (full-covars): 0.00352 PGS R2 (no covariates): 8e-05 [-0.00076, 0.00091] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006682 | PSS006518| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Temporal Gyrus, posterior division (L) | — | — | R²: 0.15146 [0.14326, 0.15966] Incremental R2 (full-covars): 0.00735 PGS R2 (no covariates): 0.00887 [0.00656, 0.01119] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006683 | PSS006519| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Temporal Gyrus, posterior division (L) | — | — | R²: 0.13939 [0.12516, 0.15362] Incremental R2 (full-covars): 0.01367 PGS R2 (no covariates): 0.01645 [0.01086, 0.02203] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006684 | PSS006520| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Inferior Temporal Gyrus, posterior division (L) | — | — | R²: 0.11625 [0.1117, 0.1208] Incremental R2 (full-covars): 0.00446 PGS R2 (no covariates): 0.00566 [0.00453, 0.00679] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006516 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006517 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006518 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006519 | — | — | 329 individuals | — | South Asian | — | UKB | — |
| PSS006520 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |